Evidence map›Paper›PMID 31139940›Full record

ArticleMedical molecular morphology2020

Multiplex PCR analysis of apocrine lesions shows frequent PI3K-AKT pathway mutations in both benign and malignant apocrine breast tumors.

Naoki Kanomata, Rin Yamaguchi, Junichi Kurebayashi, Takuya Moriya

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Article in Medical molecular morphology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Naoki KanomataDepartment of Pathology, St. Luke's International Hospital, Akashi-cho 9-1, Chuo-ku, Tokyo, 104-8560, Japan. kanomnao@luke.ac.jp.ORCID http://orcid.org/0000-0002-0172-4524
Rin YamaguchiDepartment of Pathology and Laboratory Medicine, Kurume University Medical Center, Kurume, Fukuoka, Japan.
Junichi KurebayashiDepartment of Breast and Thyroid Surgery, Kawasaki Medical School, Kurashiki, Japan.
Takuya MoriyaDepartment of Pathology, Kawasaki Medical School, Kurashiki, Okayama, Japan.

Funding

Kawasaki Medical School 25K17
6 · The paper itself

Abstract

Pathological diagnosis of intraductal apocrine lesions can be challenging, because even benign apocrine lesions often show atypical cytology, and immunohistochemistry is of little assistance. A new diagnostic method for apocrine lesions is desirable. The mutations present in apocrine lesions have not been well studied. We performed a MassARRAY multiplex polymerase chain reaction (PCR) study of benign and malignant apocrine lesions, which included 152 mutations of 18 genes. We found that four of 11 benign lesions showed AKT1 or PIK3CA mutations, one of four noninvasive apocrine carcinomas showed a FBX4 mutation, two of 15 invasive apocrine carcinomas showed a PIK3CA mutation, and one invasive apocrine carcinoma showed both PIK3CA and TP53 mutations. The mutation frequency did not differ significantly between benign and malignant lesions (p = 0.683). We demonstrated that both benign and malignant apocrine lesions may contain mutations of genes in the PI3K-AKT pathway, this pathway could be a good therapeutic target of these diseases.

Indexed as

AdultBreast NeoplasmsClass I Phosphatidylinositol 3-KinasesDiagnosis, DifferentialF-Box ProteinsFemaleGene ExpressionHumansMultiplex Polymerase Chain ReactionMutationNeoplasm ProteinsNeoplasmsPapilloma, IntraductalProto-Oncogene Proteins c-aktTumor Suppressor Protein p53AKT1 protein, humanClass I Phosphatidylinositol 3-KinasesF-Box ProteinsFBXO4 protein, humanNeoplasm ProteinsPIK3CA protein, humanProto-Oncogene Proteins c-aktTP53 protein, humanTumor Suppressor Protein p53AKTApocrine cancerBreastMultiplex PCRMutationPapillomaPIK3CA

Identifiers

PMID31139940

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