Evidence map›Paper›PMID 31139925›Full record

ArticleCancer immunology, immunotherapy : CII2019

Impact of combination immunochemotherapies on progression of 4NQO-induced murine oral squamous cell carcinoma.

Sonja Ludwig, Chang-Sook Hong, Beatrice M Razzo, Kellsye P L Fabian, Manoj Chelvanambi, Stephan Lang, Walter J Storkus, Theresa L Whiteside

Abstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Trends in immunotherapy for oral squamous cell carcinoma.Cellular oncology (Dordrecht, Netherlands) · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. 2-Phenethylamines in Medicinal Chemistry: A Review.Molecules (Basel, Switzerland) · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Frontiers in pharmacology · 2022
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sonja LudwigDepartment of Otorhinolaryngology and Head and Surgery, University Hospital Essen, Essen, Germany.
Chang-Sook HongUniversity of Pittsburgh, Medical Center (UPMC), Hillman Cancer Center, Suite 1.32b, 5117 Centre Ave, Pittsburgh, PA, 15213, USA.
Beatrice M RazzoUniversity of Pittsburgh, Medical Center (UPMC), Hillman Cancer Center, Suite 1.32b, 5117 Centre Ave, Pittsburgh, PA, 15213, USA.
Kellsye P L FabianDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
Manoj ChelvanambiDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
Stephan LangDepartment of Otorhinolaryngology and Head and Surgery, University Hospital Essen, Essen, Germany.
Walter J StorkusUniversity of Pittsburgh, Medical Center (UPMC), Hillman Cancer Center, Suite 1.32b, 5117 Centre Ave, Pittsburgh, PA, 15213, USA.
Theresa L WhitesideUniversity of Pittsburgh, Medical Center (UPMC), Hillman Cancer Center, Suite 1.32b, 5117 Centre Ave, Pittsburgh, PA, 15213, USA. whitesidetl@upmc.edu.

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Restoring anti-tumor immunity in the microenvironment of head and neck cancerR01CA168628 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITESIDE, THERESA L. · 2013 to 2017
$1.7M
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA168628NIH HHS R01-CA168268
6 · The paper itself

Abstract

Advanced oral squamous cell carcinomas (OSCC) have limited therapeutic options. Although immune therapies are emerging as a potentially effective alternative or adjunct to chemotherapies, the therapeutic efficacy of combination immune chemotherapies has yet to be determined. Using a 4-nitroquinolone-N-oxide (4NQO) orthotopic model of OSCC in immunocompetent mice, we evaluated the therapeutic efficacy of single- and combined-agent treatment with a poly-epitope tumor peptide vaccine, cisplatin and/or an A

Indexed as

4-Nitroquinoline-1-oxideAnimalsAntineoplastic Combined Chemotherapy ProtocolsCancer VaccinesCisplatinCombined Modality TherapyFemaleImmunotherapyMiceMice, Inbred C57BLMouth NeoplasmsNeoplasms, ExperimentalSquamous Cell Carcinoma of Head and NeckTreatment OutcomeTriazinesTriazoles4-Nitroquinoline-1-oxideCancer VaccinesCisplatinTriazinesTriazolesVaccines, SubunitZM 2413854NQO modelA2AR inhibitionCarcinogenesisChemotherapyOral squamous cell carcinomaVaccination

Identifiers

PMID31139925
PMCPMC10577812

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.