Evidence map›Paper›PMID 31139918›Full record

Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2019

Dynamic intraoperative optical coherence tomography for inverted internal limiting membrane flap technique in large macular hole surgery.

Lyubomyr M Lytvynchuk, Christiane I Falkner-Radler, Katharina Krepler, Carl G Glittenberg, Daniel Ahmed, Goran Petrovski, Birgit Lorenz, Siamak Ansari-Shahrezaei, Susanne Binder

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Inverted internal limiting membrane flap technique in eyes with large idiopathic full-thickness macular hole: long-term functional and morphological outcomes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  10. Review
  11. Application of subretinal fluid to close refractory full thickness macular holes: treatment strategies and primary outcome: APOSTEL study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
    Article
  12. MANAGEMENT OF LARGE OR RECURRENT MACULAR HOLES.Current ophthalmology reports · 2020
    Article
  13. Review
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Lyubomyr M LytvynchukDepartment of Ophthalmology, Justus Liebig University, University Hospital Giessen and Marburg GmbH, Campus Giessen, Friedrichstrasse 18, 35392, Giessen, Germany. lyubomyr.lytvynchuk@gmail.com.
Christiane I Falkner-RadlerKarl Landsteiner Institute for Retinal Research and Imaging, Juchgasse 25, 1030, Vienna, Austria.
Katharina KreplerKarl Landsteiner Institute for Retinal Research and Imaging, Juchgasse 25, 1030, Vienna, Austria.
Carl G GlittenbergKarl Landsteiner Institute for Retinal Research and Imaging, Juchgasse 25, 1030, Vienna, Austria.
Daniel AhmedKarl Landsteiner Institute for Retinal Research and Imaging, Juchgasse 25, 1030, Vienna, Austria.
Goran PetrovskiCenter for Eye Research, Department of Ophthalmology, Oslo University Hospital and University of Oslo, Oslo, Norway.
Birgit LorenzDepartment of Ophthalmology, Justus Liebig University, University Hospital Giessen and Marburg GmbH, Campus Giessen, Friedrichstrasse 18, 35392, Giessen, Germany.
Siamak Ansari-ShahrezaeiKarl Landsteiner Institute for Retinal Research and Imaging, Juchgasse 25, 1030, Vienna, Austria.
Susanne BinderDepartment of Ophthalmology, Rudolf Foundation Hospital, Juchgasse 25, 1030, Vienna, Austria.
Rudolfinerhaus Hospital · ATUniversity of Giessen · DEUniversity of Oslo · NOUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesTo assess the efficacy of dynamic intraoperative spectral-domain optical coherence tomography (iSD-OCT) imaging for inverted internal limiting membrane (ILM) flap technique (IILMFT) in large macular hole (MH) surgery. SUBJECTS/

methodsProspective, non-randomized, observational study was conducted on 8 eyes of 7 patients with large, chronic and recurrent MHs, which were treated by pars plana vitrectomy (PPV) with IILMFT. All patients underwent standard pre- and postoperative examination. The iSD-OCT imaging was performed using microscope integrated systems before, during, and after ILM peeling. The iSD-OCT data were post-processed using graphic software and reviewed for tissue behavior and instruments position.

resultsThe real-time iSD-OCT-assisted IILMFT allowed for real-time imaging of the entire surgery with visualization of the MH, vitreoretinal instruments, and all steps of inverted ILM flap formation. In spite of shadowing created by the steel instruments, it was possible to follow and control the distance between the instrument tips and retinal layers. Dynamic imaging of the surgical maneuvers including ILM peeling and mechanical apposition of MH edges revealed the iatrogenic impact on the retina (depression and appearance of hyporeflective zones). iSD-OCT imaging could confirm the proper position of the inverted ILM flap at the very end of the surgery after fluid-air exchange.

conclusionsiSD-OCT imaging is an effective tool for learning and performing a well-controlled and safe inverted ILM flap technique in patients with large MH. Clinical significance of the structural iSD-OCT findings has to be further studied.

Indexed as

Surgical FlapsVisual AcuityAdultAgedBasement MembraneFemaleFollow-Up StudiesHumansIntraoperative PeriodMacula LuteaMaleMiddle AgedProspective StudiesRetinal PerforationsTomography, Optical CoherenceTreatment OutcomeIntraoperative spectral-domain optical coherence tomography (iSD-OCT)Inverted internal limiting membrane (ILM) flap techniqueLarge macular hole (MH)Pars plana vitrectomyPost-processing

Identifiers

PMID31139918
OpenAlexW2947060913

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.