Evidence map›Paper›PMID 31139896›Full record

ReviewCurrent genetics2019

Advances in linking polyketides and non-ribosomal peptides to their biosynthetic gene clusters in Fusarium.

Mikkel Rank Nielsen, Teis Esben Sondergaard, Henriette Giese, Jens Laurids Sørensen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Biosynthesis Regulation of Secondary Metabolite Production inJournal of fungi (Basel, Switzerland) · 2025
    Review
  2. Genome Sequencing of aInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Gramiketides, Novel Polyketide Derivatives ofJournal of fungi (Basel, Switzerland) · 2022
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mikkel Rank NielsenDepartment of Chemistry and Bioscience, Aalborg University, Niels Bohrs Vej 8, 6700, Esbjerg, Denmark.ORCID http://orcid.org/0000-0003-2408-9444
Teis Esben SondergaardDepartment of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Plads 7H, 9220, Aalborg Ø, Denmark.ORCID http://orcid.org/0000-0002-4455-7498
Henriette GieseDepartment of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Plads 7H, 9220, Aalborg Ø, Denmark.ORCID http://orcid.org/0000-0002-5284-4155
Jens Laurids SørensenDepartment of Chemistry and Bioscience, Aalborg University, Niels Bohrs Vej 8, 6700, Esbjerg, Denmark. jls@bio.aau.dk.ORCID http://orcid.org/0000-0002-2392-5343

Funding

Novo Nordisk Fonden NNF15OC0016028
6 · The paper itself

Abstract

The eukaryotic ascomycete genus Fusarium comprises many species capable of producing secondary metabolites important for agriculture, health, and biotechnology. Filamentous fungi share common physiological features, but even within Fusarium, there are significant differences that affect the success of biotechnological methods used to unravel biosynthetic pathways. The aim of this review is to describe the different methods that have successfully been used throughout the genus Fusarium to identify the products of novel biosynthetic pathways. The results are presented in tables to give the reader an overview and thereby enable the selection of the most appropriate method to the problem, regarding both species and target products. Significant work has gone into characterization of the underlying molecular genetics of secondary metabolites, but still, the products of only 25-30% of predicted gene clusters have been identified. In this review, we highlight existing knowledge and encourage the development of new techniques and strategies to provide access to the many unknown polyketide and non-ribosomal peptide products that await discovery in Fusarium.

Indexed as

Peptide Biosynthesis, Nucleic Acid-IndependentBiosynthetic PathwaysFusariumGene Expression Regulation, FungalGene Knockout TechniquesHistonesPeptidesPeptide SynthasesPolyketidesPolyketide SynthasesProtoplastsTransformation, GeneticHistonesPeptidesPeptide SynthasesPolyketidesPolyketide SynthasesFusariumGene clusterNatural productsNRPSPKSSecondary metabolites

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.