Evidence map›Paper›PMID 31139613›Full record

ArticleFrontiers in chemistry2019

Self-Assembled Thin-Layer Glycomaterials With a Proper Shell Thickness for Targeted and Activatable Cell Imaging.

Chao Zhang, Guanzhen Wang, Hai-Hao Han, Xi-Le Hu, Robert A Field, Guo-Rong Chen, Jia Li, Bing Ye, Xiao-Peng He, Yi Zang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Chao ZhangEmergency Department, Jinan Children's Hospital, Jinan, China.
Guanzhen WangState Key Laboratory of Drug Research, National Center for Drug Screening, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, Shanghai, China.
Hai-Hao HanKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.
Xi-Le HuKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.
Robert A FieldDepartment of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, United Kingdom.
Guo-Rong ChenKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.
Jia LiState Key Laboratory of Drug Research, National Center for Drug Screening, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, Shanghai, China.
Bing YeEmergency Department, Jinan Children's Hospital, Jinan, China.
Xiao-Peng HeKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.
Yi ZangState Key Laboratory of Drug Research, National Center for Drug Screening, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, Shanghai, China.
East China University of Science and Technology · CNNational Center for Drug Screening · CNJohn Innes Centre · GBShanghai Institute of Materia Medica · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The construction of targeted and activatable materials can largely improve the precision of disease diagnosis and therapy. However, the currently developed systems either target a transmembrane antigen or are activatable to release imaging and/or therapeutic reagents intracellularly. Here, we develop a simple thin-layer glycomaterial through the self-assembly between fluorescent glycoprobes, in which the carbohydrate-targeting reagent and the fluorophore are linked to each other by polyethylene glycol with a suitable chain length, and thin-layer manganese dioxide. The fluorogenic material developed is both capable of targeting a transmembrane glycoprotein receptor and fluorescently activatable by intracellular biothiols. The shell thickness of the material was determined to be important for achieving the biothiol-induced activation of fluorescence. This research might provide insight into the development of precision-enhanced self-assembled materials for disease theranostics.

Indexed as

activatablefluorescenceimagingprecisionreceptor

Identifiers

PMID31139613
PMCPMC6517789
OpenAlexW2944726804

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.