ReviewFrontiers in pediatrics2019
Review of the Literature on Current Changes in the Timing of Pubertal Development and the Incomplete Forms of Early Puberty.
Review in Frontiers in pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- The Effects of Dairy Product Supplementation on Bone Health Indices in Children Aged 3 to 18 Years: A Meta-Analysis of Randomized Controlled Trials.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Diet and Nutrients Intakes during Infancy and Childhood in Relation to Early Puberty: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Least Equal When Most Teachable: The Biodevelopmental Learning Opportunities and Outcomes Model of Gender Differences in Sexuality.Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc · 2026Review
- The Role of Pelvic Ultrasound in Monitoring and Predicting Therapeutic Efficacy of GnRHa for Central Precocious Puberty.Journal of clinical ultrasound : JCU · 2026Article
- Functional brain network correlates of pubertal timing and depressive symptoms in preadolescence.bioRxiv : the preprint server for biology · 2026Article
- Prospective associations of sleep duration and screen time with transition from overweight/obesity to normal BMI in U.S. adolescents.International journal of obesity (2005) · 2026Article
- Trends in central precocious puberty incidence in Japan during the COVID-19 pandemic.Frontiers in pediatrics · 2026Article
- Phenotype-specific 25-hydroxyvitamin D and fat-soluble vitamin profiles in girls with pediatric endocrine disorders: a large cross-sectional study.Frontiers in nutrition · 2026Article
- The association between weight-adjusted waist index and physical fitness index among Chinese adolescents.Scientific reports · 2025Article
- The role of the first interpersonal trauma exposure's developmental period on fear regulation processes among adult women.European journal of psychotraumatology · 2025Article
- Distinct attention network topology and dynamics and their relations with pubertal hormones in preadolescent boys and girls with binge eating.Translational psychiatry · 2025Article
- [Peak growth hormone and insulin-like growth factor 1 levels in girls with isolated premature thelarche and their predictive value for central precocious puberty].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Trend in body mass index during childhood in 460 girls with idiopathic central precocious puberty.Endocrine connections · 2025Article
- Internal Exposure to BTEX in Tropical Children: Does Exposure Speed Up Pubertal Development?Antioxidants (Basel, Switzerland) · 2025Article
- Maternal pre-pregnancy overweight/obesity, in-utero exposure to toxic heavy metals, and offspring age at peak height velocity: A prospective birth cohort study.Environmental research · 2025Article
- Puberty, but not precocious puberty is influenced by weight gain in the first years of life.Endocrine · 2025Article
- Burden and contributing factors to overweight and obesity in young adolescents in Addis Ababa, Ethiopia.Maternal & child nutrition · 2025Article
- Insulin-like growth factor 1 as a diagnostic marker of progressive central precocious puberty: a prospective study.European journal of pediatrics · 2025Article
- Associations between structural stigma and earlier pubertal timing persist for 1 year among Black girls and Latinx youth.Scientific reports · 2025Article
- Longitudinal Sex-at-Birth and Age Analyses of Cortical Structure in the ABCD Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Puberty is a sensitive period of life characterized by the appearance of secondary sex characteristics which leads to a complete sexual maturation. It physiologically starts between the age of 8 and 13 years in girls and 9 and 14 years in boys. In the last two decades, several studies have showed that start of puberty has moved up to younger ages by 12-18 months, and some of the hypotheses trying to explain this change include the role of nutritional status and obesity and the influence of extrinsic factors such as exposure to endocrine-disrupting chemicals (EDCs), as well. The hypothalamic-hypophysis-gonadal axis develops during embryogenesis, and except for a period of activation immediately after birth, remains suppressed until the onset of pubertal development. At the beginning of puberty, the pulse generator is reactivated, probably due to progressive stimulatory influences on GnRH neurons from glial signals and neurotrasmitters. Kisspeptin and its receptor play a fundamental role in this phase. Premature Pubarche/Adrenarche, Premature Thelarche, and Premature Menarche are incomplete forms of precocious pubertal development that have their origin in endocrine mechanisms that only recently have started to be understood. It is important to distinguish these forms from the complete ones in order to reassure patients and parents about the non-evolution of pubertal progression and avoid non-useful treatments with analogous LHRH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.