Evidence map›Paper›PMID 31139552›Full record

ArticleChemistryOpen2019

Experimental and Theoretical Approaches in the Study of Phenanthroline-Tetrahydroquinolines for Alzheimer's Disease.

Yorley Duarte, Margarita Gutierrez, Rocío Álvarez, Jans H Alzate-Morales, Jorge Soto-Delgado

Abstract read
In one paragraph

Article in ChemistryOpen, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yorley DuarteFacultad de Ciencias de la Vida, Center for Bioinformatics and Integrative Biology Universidad Andrés Bello Santiago 8370146 Chile.ORCID 0000-0002-8127-7540
Margarita GutierrezLaboratorio Síntesis Orgánica, Instituto de Química de Recursos Naturales Universidad de Talca Casilla 747 Talca Chile.
Rocío ÁlvarezLaboratory of Pharmacology, Faculty of Pharmacy Universidad de Valparaíso Gran Bretaña 1093 2360102 Valparaíso Chile.
Jans H Alzate-MoralesCentro de Bioinformática y Simulación Molecular Universidad de Talca 2 Norte 685, Casilla 721 Chile.
Jorge Soto-DelgadoDepartamento de Ciencias Químicas, Facultad de Ciencias Exactas Universidad Andres Bello Quillota 980 Viña del Mar Chile.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The imino-Diels-Alder reaction is one of the most common strategies in organic chemistry and is an important tool for providing a broad spectrum of biologically active heterocyclic systems. A combined theoretical and experimental study of the imino-Diels-Alder reaction is described. The new phenanthroline-tetrahydroquinolines were evaluated as cholinesterase inhibitors. Their cytotoxicity in human neuroblastoma SH-SY5Y cells was also evaluated. The theoretical results suggest that compounds formation in stages can be explained by

Indexed as

acetylcholinesteraseAlzheimer's disease imino-Diels-Alderdensity functional theorytetrahydroquinolines

Identifiers

PMID31139552
PMCPMC6528641

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.