ArticleCureus2019
Safety and Efficacy of Lattice Radiotherapy in Voluminous Non-small Cell Lung Cancer.
Article in Cureus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Spatially fractionated radiation therapy for bulky tumors: a systematic review of clinical outcomes and dosimetric challenges.Radiation oncology (London, England) · 2026Pooled it
- Effectiveness and Safety of Lattice Radiotherapy in Treating Large Volume Tumors: A Systematic Review and Meta-analysis Based on Single-arm Clinical Studies.Balkan medical journal · 2025Pooled it
- Preliminary results from a phase II trial of spatially fractionated radiotherapy combined with immunotherapy and anti-angiogenic therapy in patients with bulky solid tumors: early evidence of promising efficacy and favorable safety.Radiation oncology (London, England) · 2026Trial
- Proton pencil beam scanning lattice radiotherapy: technical implementation and comparison against photon-based delivery.The British journal of radiology · 2026Article
- Feasibility, safety, and clinical outcomes analysis of dense-lattice radiation therapy in palliative care for cancer patients´.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Photon minibeam-based LATTICE radiotherapy for small and medium-sized tumors: A dosimetric planning study.Medical physics · 2026Article
- Development and validation of an automated evaluation system for lattice radiotherapy using a commercial treatment planning system scripting API.Journal of applied clinical medical physics · 2026Article
- A multidisciplinary experimental and methodological investigation of electron and proton minibeams in the framework of the INFN MIRO project.Medical physics · 2026Article
- Spatially fractionated radiotherapy and immunotherapy: a synergistic strategy for systemic anti-tumor immunity.Journal of translational medicine · 2026Review
- A single-field-each-peak optimization method for motion-robust proton LATTICE therapy.Medical physics · 2026Article
- Article
- Spatially fractionated radiation therapy (SFRT): a scoping review of dosimetric and biological evidence supporting a valley dose-driven translational framework.Radiation oncology (London, England) · 2026Article
- Dosimetric comparison of lattice radiotherapy across three modern linear accelerator platforms.Precision radiation oncology · 2026Article
- A preclinical setup for spatially fractionated radiation therapy with electrons.Medical physics · 2026Article
- Respiratory motion effects and plan robustness for lattice radiation therapy.Frontiers in oncology · 2026Article
- Case Report: Image-guided adaptive lattice radiotherapy for a 2,772-cc ulcerative triple-negative breast cancer.Frontiers in oncology · 2026Article
- Dose optimization with fully flexible vertex positioning for LATTICE radiotherapy.Medical physics · 2026Article
- Spatially fractionated radiotherapy for re-irradiation: feasibility, safety, treatment planning, and outcomes.Clinical and translational radiation oncology · 2026Article
- Individualized VMAT lattice radiotherapy on a standard flattening-filter linear accelerator for advanced bulky tumors: a retrospective feasibility and early clinical experience.Frontiers in oncology · 2026Article
- Integration of X-Ray and γ-Ray technologies in lattice radiotherapy: a novel approach for optimizing dose delivery in large-volume non-small cell lung cancer.Radiation oncology (London, England) · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective Lattice radiotherapy (LRT) is a novel technique of delivering heterogeneous doses of radiation to voluminous tumors not amenable to surgery. Built from the conventional two-dimensional grid, LRT utilizes the power of new technology, three-dimensional radiation allowing the delivery of higher doses of radiation to small spheres, also called vertices, inside bulky tumors while limiting exposure to surrounding healthy tissue. The main goals of the study were the evaluation of tumor response and the overall safety of LRT in this cohort of patients with bulky non-small cell lung cancer. Materials and methods During a seven-year period, 10 patients with non-small cell lung cancer (NSCLC), who presented with bulky, unresectable tumors, were treated using a single fraction of LRT followed by conventionally fractionated radiation. Patients received one initial LRT fraction of 18 Gy in the vertices and 3 Gy in the periphery. After the LRT, all patients continued with conventional radiation: 25 to 29 daily fractions of 1.8 Gy to 2 Gy. Results With a median follow-up of six months (range: one to 71 months), the mean decrease in tumor volume was 42%. The overall survival of the entire group ranged from four to 86 months (mean 22, median 16). There was no mortality related to LRT. No significant acute or chronic toxicity was noted. Conclusion In this small cohort, LRT appears to be a safe and effective modality to treat bulky NSCLC. Further research is needed to establish its efficacy in the management of voluminous NSCLC.
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