ArticleMultiple sclerosis international2019
Repeated Working Memory Training Improves Task Performance and Neural Efficiency in Multiple Sclerosis Patients and Healthy Controls.
Article in Multiple sclerosis international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05270239 (Neurorehabilitation and Functional Recovery in Multiple Sclerosis), which is not on this map. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurorehabilitation and Functional Recovery in Multiple Sclerosis: Assessing Two Therapeutic Strategies Using Functional Magnetic Resonance Imaging.
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- What Is Targeted When We Train Working Memory? Evidence From a Meta-Analysis of the Neural Correlates of Working Memory Training Using Activation Likelihood Estimation.Frontiers in psychology · 2022Pooled it
- Memory rehabilitation for people with multiple sclerosis.The Cochrane database of systematic reviews · 2021Pooled it
- The Effects of Cognitive Training on Brain Network Activity and Connectivity in Aging and Neurodegenerative Diseases: a Systematic Review.Neuropsychology review · 2020Pooled it
- Meta-analysis of computerised working memory training: behavioural gains, training parameters, transfer mechanisms, and neural correlates.NPJ digital medicine · 2026Article
- Exploring the n-back task: insights, applications, and future directions.Frontiers in human neuroscience · 2025Review
- Consistent activation differences versus differences in consistent activation: Evaluating meta-analytic contrasts.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Altered phase and nonphase EEG activity expose impaired maintenance of a spatial-object attentional focus in multiple sclerosis patients.Scientific reports · 2020Article
- Working memory training increases neural efficiency in Parkinson's disease: a randomized controlled trial.Brain communications · 2020Article
- Pre-training working memory/information processing capabilities and brain atrophy limit the improving effects of cognitive training.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveTo explore the effectiveness of a specific working memory (WM) training program in MS patients and healthy controls (HC).
method29 MS patients and 29 matched HC were enrolled in the study. MS and HC were randomly split into two groups: nontraining groups (15HC/14 MS) and training groups (14 HC/15 MS). Training groups underwent adaptive n-back training (60 min/day; 4 days). Functional magnetic resonance imaging (fMRI) was used to monitor brain activity during n-back performance (conditions: 0-back, 2-back, and 3-back) at 3 time points: (1) baseline, (2) post-training (+7days), and (3) follow-up (+35days).
resultsIn post-training and follow-up fMRI sessions, trained groups (HC and MS patients) exhibited significant reaction time (RT) reductions and increases in Correct Responses (CRs) during 2-back and 3-back performance. This improvement of task performance was accompanied by a decrease in brain activation in the WM frontoparietal network. The two effects were significantly correlated.
conclusionsAfter WM training, both cognitively preserved MS patients and HC participants showed task performance improvement made possible by neuroplastic processes that enhanced neural efficiency.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.