Observational studyAntimicrobial resistance and infection control2019
Patterns in the longitudinal oropharyngeal microbiome evolution related to ventilator-associated pneumonia.
Observational study in Antimicrobial resistance and infection control, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04849039 ("Pulmonary Microbiota and Related Immunity Role in Predicting Ventilator Associated- Pneumonia), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
"Pulmonary Microbiota and Related Immunity Role in Predicting Ventilator Associated- Pneumonia (VAP) Development in Mechanical Ventilated Patients"
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Probiotic in the prevention of ventilator-associated pneumonia in critically ill patients: evidence from meta-analysis and trial sequential analysis of randomized clinical trials.BMC pulmonary medicine · 2022Pooled it
- Effect of ventilation modalities on the early prognosis of patients with poststroke sleep apnea.Annals of clinical and translational neurology · 2024Trial
- Airway tracers and biomarkers for aspiration detection and VAP prediction in ICU patients with tracheal tubes: a systematic review and diagnostic accuracy meta-analysis.Annals of intensive care · 2026Review
- Spatio-temporal differences and associations between upper and lower respiratory microbiota in ventilator-associated pneumonia.Frontiers in cellular and infection microbiology · 2026Article
- Relative faecal abundance to predict extended-spectrum β-lactamase-producing Enterobacterales related ventilator‑associated pneumonia.Annals of intensive care · 2025Article
- Microbiome and Mycobiome Analyses of Continuous Positive Airway Pressure Devices.Clinical and experimental otorhinolaryngology · 2024Article
- Robust airway microbiome signatures in acute respiratory failure and hospital-acquired pneumonia.Nature medicine · 2023Article
- Association between oral microbial dysbiosis and poor functional outcomes in stroke-associated pneumonia patients.BMC microbiology · 2023Observational
- The gut microbiota composition is linked to subsequent occurrence of ventilator-associated pneumonia in critically ill patients.Microbiology spectrum · 2023Article
- Narrative review of application of metagenomic approaches to study the link between oropharyngeal microbiome and infectious diseases.Frontiers in microbiology · 2023Review
- Temporal dynamics of oropharyngeal microbiome among SARS-CoV-2 patients reveals continued dysbiosis even after Viral Clearance.NPJ biofilms and microbiomes · 2022Article
- Effect of invasive mechanical ventilation on the diversity of the pulmonary microbiota.Critical care (London, England) · 2022Review
- Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies.Intensive & critical care nursing · 2022Article
- Correlation of ICU Nurses' Cognitive Level with Their Attitude and Behavior toward the Prevention of Ventilator-Associated Pneumonia.Journal of healthcare engineering · 2022Article
- Temporal airway microbiome changes related to ventilator-associated pneumonia in children.The European respiratory journal · 2021Article
- Reconsidering ventilator-associated pneumonia from a new dimension of the lung microbiome.EBioMedicine · 2020Review
- Semi-quantitative cultures of throat and rectal swabs are efficient tests to predict ESBL-Enterobacterales ventilator-associated pneumonia in mechanically ventilated ESBL carriers.Intensive care medicine · 2020Article
- Pathogenesis and therapeutic opportunities of gut microbiome dysbiosis in critical illness.Gut microbesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The aim of the study was to evaluate the composition and the temporal evolution of the oropharyngeal microbiome in antibiotic-naïve patients requiring mechanical ventilation and to gain new insights into the pathogenesis of ventilator-associated pneumonia (VAP). Methods: Prospective, observational single-center nested case-control study. Patients with acute critical illness and anticipated duration of mechanical ventilation > 4 days were eligible. We took oropharyngeal swabs (and if available, tracheal secretions) daily, starting at the day of intubation. The microbiota was characterized by 16S rRNA high-throughput sequencing and compared between patients developing VAP versus controls. Results: Five patients developed VAP. In three patient the causative pathogens were Enterobacteriaceae and in two Conclusions: In acutely-ill patients who developed enterobacterial VAP the causative pathogen gained access to the oropharynx early after starting mechanical ventilation and outgrew the commensal members of the microbiome. Whether a specific pattern of the oropharyngeal microbiome between days three to five of mechanical ventilation may predict VAP enterobacterial VAP has to be evaluated in further studies.
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