Evidence map›Paper›PMID 31139189›Full record

ArticleFrontiers in immunology2019

Immune Correlates of Disease Progression in Linked HIV-1 Infection.

Michael Tuen, Jude S Bimela, Andrew N Banin, Shilei Ding, Gordon W Harkins, Svenja Weiss, Vincenza Itri, Allison R Durham, Stephen F Porcella, Sonal Soni and 17 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Michael TuenDepartment of Pathology, New York University School of Medicine, New York, NY, United States.
Jude S BimelaDepartment of Pathology, New York University School of Medicine, New York, NY, United States.
Andrew N BaninDepartment of Pathology, New York University School of Medicine, New York, NY, United States.
Shilei DingCentre de Recherche du CHUM, Montréal, QC, Canada.
Gordon W HarkinsSouth African MRC Bioinformatics Unit, South African National Bioinformatics Institute, University of the Western Cape, Bellville, South Africa.
Svenja WeissDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Vincenza ItriDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Allison R DurhamDivision of Intramural Research, National Institutes of Health-National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States.
Stephen F PorcellaGenomics Unit, Research Technologies Branch, Division of Intramural Research, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, United States.
Sonal SoniDepartment of Pathology, New York University School of Medicine, New York, NY, United States.
Luzia MayrDepartment of Pathology, New York University School of Medicine, New York, NY, United States.
Josephine MeliMedical Diagnostic Center, Yaoundé, Cameroon.
Judith N TorimiroFaculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
Marcel TongoCenter of Research for Emerging and Re-Emerging Diseases, Institute of Medical Research and Study of Medicinal Plants, Yaoundé, Cameroon.
Xiaohong WangVeterans Affairs New York Harbor Healthcare Systems, New York, NY, United States.
Xiang-Peng KongDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, United States.
Arthur NádasNew York University School of Medicine, Institute of Environmental Medicine, New York, NY, United States.
Daniel E KaufmannCentre de Recherche du CHUM, Montréal, QC, Canada.
Zabrina L BrummeFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Aubin J NanfackDepartment of Pathology, New York University School of Medicine, New York, NY, United States.
Thomas C QuinnDivision of Intramural Research, National Institutes of Health-National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States.
Susan Zolla-PaznerDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Andrew D ReddDivision of Intramural Research, National Institutes of Health-National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States.
Andrés FinziCentre de Recherche du CHUM, Montréal, QC, Canada.
Miroslaw K GornyDepartment of Pathology, New York University School of Medicine, New York, NY, United States.
Phillipe N NyambiDepartment of Pathology, New York University School of Medicine, New York, NY, United States.
Ralf DuerrDepartment of Pathology, New York University School of Medicine, New York, NY, United States.

Funding

BELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral EradicationUM1AI126617 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JONES, R. BRAD, NIXON, DOUGLAS F · 2016 to 2020
$28.1M
International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
Viral Evolution and Humoral Immune Response to Dual HIV-1 InfectionR01AI083142 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORNY, MIROSLAW K · 2010 to 2015
$2.6M
Training Program on HIV Diversity and Drug Resistance-Enhancing Research CapacityD43TW009604 · FIC · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORNY, MIROSLAW K · 2013 to 2017
$1.4M
Viral Evolution and Humoral Immune Response to Dual HIV-1 InfectionR56AI083142 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NYAMBI, PHILLIPE N · 2009 to 2009
$407k
FIC NIH HHS D43 TW009604NIAID NIH HHS R01 AI083142NIAID NIH HHS R56 AI083142NIAID NIH HHS UM1 AI126617
6 · The paper itself

Abstract

Genetic and immunologic analyses of epidemiologically-linked HIV transmission enable insights into the impact of immune responses on clinical outcomes. Human vaccine trials and animal studies of HIV-1 infection have suggested immune correlates of protection; however, their role in natural infection in terms of protection from disease progression is mostly unknown. Four HIV-1

Indexed as

Antibodies, NeutralizingAntibody-Dependent Cell CytotoxicityCD4-CD8 RatioDisease Progressionenv Gene Products, Human Immunodeficiency VirusFemaleHIV-1HIV AntibodiesHIV InfectionsHumansImmunoglobulin AImmunoglobulin GMaleAntibodies, Neutralizingenv Gene Products, Human Immunodeficiency VirusHIV AntibodiesImmunoglobulin AImmunoglobulin GADCCBEASTepidemiologically-linked infectionhuman immunodeficiency virus (HIV)IgA/IgG ratioprotective immune parameters and host factorsV1V2 antibody bindingviral signature K169

Identifiers

PMID31139189
PMCPMC6527802

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.