Evidence map›Paper›PMID 31139180›Full record

ArticleFrontiers in immunology2019

Chemerin Suppresses Breast Cancer Growth by Recruiting Immune Effector Cells Into the Tumor Microenvironment.

Russell K Pachynski, Ping Wang, Nicole Salazar, Yayue Zheng, Leona Nease, Jesse Rosalez, Weng-In Leong, Gurpal Virdi, Keith Rennier, Woo Jae Shin and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 67 citations in OpenAlex.

  1. Establishment of a Seven-Gene Signature Associated with CD8International journal of molecular sciences · 2023
    Trial
  2. Stage-Specific Proteomic Profiles in Dental Caries.Journal of dental research · 2026
    Article
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  16. Exploring the multifaceted role of obesity in breast cancer progression.Frontiers in cell and developmental biology · 2024
    Review
  17. Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Russell K PachynskiDivision of Oncology, Department of Medicine, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, United States.
Ping WangDivision of Oncology, Department of Medicine, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, United States.
Nicole SalazarDepartment of Research and Development, Palo Alto Veterans Institute for Research, Palo Alto, CA, United States.
Yayue ZhengDepartment of Research and Development, Palo Alto Veterans Institute for Research, Palo Alto, CA, United States.
Leona NeaseDepartment of Research and Development, Palo Alto Veterans Institute for Research, Palo Alto, CA, United States.
Jesse RosalezDepartment of Industrial and Systems Engineering, San José State University, San José, CA, United States.
Weng-In LeongDynavax Technologies, Berkeley, CA, United States.
Gurpal VirdiDivision of Oncology, Department of Medicine, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, United States.
Keith RennierDivision of Oncology, Department of Medicine, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, United States.
Woo Jae ShinDivision of Oncology, Department of Medicine, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, United States.
Viet NguyenDepartment of Biology, San Francisco State University, San Francisco, CA, United States.
Eugene C ButcherDepartment of Pathology, Stanford University, Stanford, CA, United States.
Brian A ZabelDepartment of Research and Development, Palo Alto Veterans Institute for Research, Palo Alto, CA, United States.
Washington University in St. Louis · USPalo Alto Veterans Institute for Research · USDynavax Technologies (United States) · USSan Francisco State University · USSan Jose State University · USStanford University · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
WOMEN'S HEALTH AGENDAU01AI025903 · NIAID · WASHINGTON UNIVERSITY · PI CLIFFORD, DAVID B · 1987 to 2006
$12.5M
NIGMS MARC UNDERGRADUATE RESEARCH TRAINING GRANTT34GM008253 · NIGMS · SAN JOSE STATE UNIVERSITY · PI OUVERNEY, CLEBER COSTA · 1988 to 2020
$8.4M
Molecular and Functional Characterization of Chemerin ReceptorsR01AI079320 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI ZABEL, BRIAN A. · 2009 to 2013
$1.7M
Chemerin in Tumor Immunity and SurveillanceR01CA169354 · NCI · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI BUTCHER, EUGENE C · 2013 to 2017
$1.7M
ENDOTHELIAL CELL BIOLOGY IN INFLAMMATIONR01GM037734 · NIGMS · STANFORD UNIVERSITY · PI BUTCHER, EUGENE C · 1987 to 2017
$938k
New Approaches to Combat CNS Inflammation: Targeting a Metabolic Enzyme in Demyelinating DiseaseI01BX004115 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI BRIAN A. ZABEL · 2019 to 2026
–
BLRD VA I01 BX004115NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA169354NIAID NIH HHS R01 AI079320NIAID NIH HHS U01 AI025903NIGMS NIH HHS R01 GM037734NIGMS NIH HHS T34 GM008253
6 · The paper itself

Abstract

Infiltration of immune cells into the tumor microenvironment (TME) can regulate growth and survival of neoplastic cells, impacting tumorigenesis and tumor progression. Correlations between the number of effector immune cells present in a tumor and clinical outcomes in many human tumors, including breast, have been widely described. Current immunotherapies utilizing checkpoint inhibitors or co-stimulatory molecule agonists aim to activate effector immune cells. However, tumors often lack adequate effector cell numbers within the TME, resulting in suboptimal responses to these agents. Chemerin (

Indexed as

Immunity, CellularAnimalsChemokinesFemaleGene Expression Regulation, NeoplasticIntercellular Signaling Peptides and ProteinsLeukocytesMammary Neoplasms, AnimalMiceMice, Inbred BALB CMice, KnockoutNeoplasm ProteinsTumor Microenvironmentchemerin protein, mouseChemokinesIntercellular Signaling Peptides and ProteinsNeoplasm Proteinsbreast cancerchemerinimmunotherapyleukocyte traffickingNK cellsRARRES2T cells

Identifiers

PMID31139180
PMCPMC6518384
OpenAlexW2943893201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.