Evidence map›Paper›PMID 31139177›Full record

ArticleFrontiers in immunology2019

Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling.

Matthew J Elder, Steve J Webster, Timothy J Fitzmaurice, Aran S D Shaunak, Martin Steinmetz, Ronnie Chee, Ziad Mallat, E Suzanne Cohen, David L Williams, J S Hill Gaston and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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  8. A population of dermal LangerinFrontiers in immunology · 2022
    Article
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  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Matthew J ElderDepartment of Medicine, School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom.
Steve J WebsterDepartment of Medicine, School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom.
Timothy J FitzmauriceDepartment of Medicine, School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom.
Aran S D ShaunakDepartment of Medicine, School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom.
Martin SteinmetzUnit 970, INSERM, Paris Cardiovascular Research Center, Paris, France.
Ronnie CheeDepartment of Immunology, Royal Free Hospital, London, United Kingdom.
Ziad MallatDivision of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
E Suzanne CohenBiopharmaceutical Research Division, AstraZeneca, Cambridge, United Kingdom.
David L WilliamsDepartment of Surgery, Center for Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.
J S Hill GastonDepartment of Medicine, School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom.
Jane C GoodallDepartment of Medicine, School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom.
University of Cambridge · GBAddenbrooke's Hospital · GBAstraZeneca (United Kingdom) · GBEast Tennessee State University · USParis Cardiovascular Research Center · FRUniversity College London · GB

Funding

Clinical/Translational Facilities for Innovative Oral Health Research at UICC06RR030655 · NCRR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI COOPER, LYNDON F · 2010 to 2010
$9.9M
Training Innate Immunity: A new approach to the treatment of SepsisR01GM119197 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI SHERWOOD, EDWARD R, WILLIAMS, DAVID L. · 2016 to 2024
$4.6M
Innate Immunity and Cardiovascular Function in SepsisR01GM083016 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI LI, CHUANFU, WILLIAMS, DAVID L. · 2009 to 2021
$3.8M
AMELIORATION OF SEPSIS BY MACROPHAGE ACTIVATIONR01GM053522 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI WILLIAMS, DAVID L. · 1996 to 2015
$3.4M
British Heart Foundation RG/15/11/31593Medical Research Council G1001765Medical Research Council MR/M020134/1NCRR NIH HHS C06 RR030655NIGMS NIH HHS R01 GM053522NIGMS NIH HHS R01 GM083016NIGMS NIH HHS R01 GM119197Versus Arthritis 19639
6 · The paper itself

Abstract

Thymic stromal lymphopoietin (TSLP) is a functionally pleotropic cytokine important in immune regulation, and TSLP dysregulation is associated with numerous diseases. TSLP is produced by many cell types, but has predominantly been characterized as a secreted factor from epithelial cells which activates dendritic cells (DC) that subsequently prime T helper (T

Indexed as

CytokinesDectin-1Dendritic CellsHumansHypoxia-Inducible Factor 1, alpha SubunitInterleukin-1betaLectins, C-TypeSignal TransductionThymic Stromal LymphopoietinCLEC7A protein, humanCytokinesDectin-1HIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitIL1B protein, humanInterleukin-1betaLectins, C-TypeThymic Stromal LymphopoietinTSLP protein, humandectin-1HIF-1αhypoxiaIL-1βROSSykTSLP

Identifiers

PMID31139177
PMCPMC6519317
OpenAlexW2944465292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.