ReviewFrontiers in neurology2019
Blood Pressure in Seizures and Epilepsy.
Review in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Cardiac structural and functional abnormalities in epilepsy: A systematic review and meta-analysis.Epilepsia open · 2023Pooled it
- Risk factors for early-onset seizures after stroke: A systematicreview and meta-analysis of 18 observational studies.Brain and behavior · 2021Pooled it
- Identification of plasma biomarkers in a PTZ-induced Sudden Unexpected Death-like model through integrated proteomics and metabolomics methods.Frontiers in medicine · 2026Article
- Kidneys in Children with Tuberous Sclerosis Complex-An Up-to-Date Review.Journal of clinical medicine · 2025Review
- Article
- Cardiovascular Effects of Antiseizure Medications for Epilepsy.CNS drugs · 2025Review
- Assessment of Cerebral Perfusion Pressure by Transcranial Doppler in Pediatric Patients with Convulsive Status Epilepticus.Indian pediatrics · 2025Article
- Prevalence of and Factors Associated with Hypertension in Children and Adolescents as Observed by German Pediatricians-A Case-Control Study.Children (Basel, Switzerland) · 2025Article
- Article
- Article
- Reduction of vascular reactivity in rat aortas following pilocarpine-induced status epilepticus.Clinics (Sao Paulo, Brazil) · 2023Article
- Wearable Epileptic Seizure Prediction System Based on Machine Learning Techniques Using ECG, PPG and EEG Signals.Sensors (Basel, Switzerland) · 2022Article
- Sepsis modulates cortical excitability and alters the local and systemic hemodynamic response to seizures.Scientific reports · 2022Article
- Validation of Continuous Monitoring System for Epileptic Users in Outpatient Settings.Sensors (Basel, Switzerland) · 2022Article
- Blood pressure and glomerular filtration rate in youth with tuberous sclerosis complex.European journal of pediatrics · 2022Article
- Autonomic manifestations of epilepsy: emerging pathways to sudden death?Nature reviews. Neurology · 2021Review
- Cerebral and systemic hemodynamic effect of recurring seizures.Scientific reports · 2021Article
- Medullary tyrosine hydroxylase catecholaminergic neuronal populations in sudden unexpected death in epilepsy.Brain pathology (Zurich, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this narrative review, we summarize the current knowledge of neurally mediated blood pressure (BP) control and discuss how recently described epilepsy- and seizure-related BP alterations may contribute to premature mortality and sudden unexpected death in epilepsy (SUDEP). Although people with epilepsy display disturbed interictal autonomic function with a shift toward predominant sympathetic activity, prevalence of arterial hypertension is similar in people with and without epilepsy. BP is transiently increased in association with most types of epileptic seizures but may also decrease in some, illustrating that seizure activity can cause both a decrease and increase of BP, probably because of stimulation or inhibition of distinct central autonomic function by epileptic activity that propagates into different neuronal networks of the central autonomic nervous system. The principal regulatory neural loop for short-term BP control is termed baroreflex, mainly involving peripheral sensors and brain stem nuclei. The baroreflex sensitivity (BRS, expressed as change of interbeat interval per change in BP) is intact after focal seizures, whereas BRS is markedly impaired in the early postictal period following generalized convulsive seizures (GCS), possibly due to metabolically mediated muscular hyperemia in skeletal muscles, a massive release of catecholamines and compromised brain stem function. Whilst most SUDEP cases are probably caused by a cardiorespiratory failure during the early postictal period following GCS, a profoundly disturbed BRS may allow a life-threatening drop of systemic BP in the aftermath of GCS, as recently reported in a patient as a plausible cause of SUDEP in a few patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.