ArticleFrontiers in aging neuroscience2019
Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories.
Article in Frontiers in aging neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hearing loss and dementia: radiologic and biomolecular basis of their shared characteristics. A systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- A harmonized framework for studying exceptional cognitive aging in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Influenza A infection accelerates disease-associated microglia formation during physiological aging.bioRxiv : the preprint server for biology · 2025Article
- The first 25 years of the Northwestern University SuperAging Program.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- An overview on microglial origin, distribution, and phenotype in Alzheimer's disease.Journal of cellular physiology · 2024Review
- Immune proteins C1q and CD47 may contribute to aberrant microglia-mediated synapse loss in the aging monkey brain that is associated with cognitive impairment.GeroScience · 2024Article
- Ferroptosis of Microglia in Aging Human White Matter Injury.Annals of neurology · 2023Article
- Microglial TREM2 at the Intersection of Brain Aging and Alzheimer's Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023Review
- Integrity of Neuronal Size in the Entorhinal Cortex Is a Biological Substrate of Exceptional Cognitive Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Transcriptomic architecture of nuclei in the marmoset CNS.Nature communications · 2022Article
- Review
- Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer's Disease Neuropathology.Journal of Alzheimer's disease : JAD · 2022Review
- Microglia activation in postmortem brains with schizophrenia demonstrates distinct morphological changes between brain regions.Brain pathology (Zurich, Switzerland) · 2022Article
- Structural integrity of the anterior mid-cingulate cortex contributes to resilience to delirium in SuperAging.Brain communications · 2022Article
- miR-214-3p Deficiency Enhances Caspase-1-Dependent Pyroptosis of Microglia in White Matter Injury.Journal of immunology research · 2022Article
- Comparative neuropathology in aging primates: A perspective.American journal of primatology · 2021Review
- Cognitive and brain cytokine profile of non-demented individuals with cerebral amyloid-beta deposition.Journal of neuroinflammation · 2021Article
- Paucity of Entorhinal Cortex Pathology of the Alzheimer's Type in SuperAgers with Superior Memory Performance.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Review
- Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors.Frontiers in aging neuroscience · 2021Article
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13 authors.
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Abstract
Activation of microglia, the primary mediators of inflammation in the brain, is a major component of gliosis and neuronal loss in a number of age-related neurodegenerative disorders, such as Alzheimer's disease (AD). The role of activated microglia in white matter, and its relationship with cognitive decline during aging are unknown. The current study evaluated microglia densities in the white matter of postmortem specimens from cognitively normal young adults, cognitively normal older adults, and cognitive "SuperAgers," a unique group of individuals over age 80 whose memory test scores are at a level equal to or better than scores of 50-to-65-year-olds. Whole hemisphere sections from cognitively normal old, young, and "SuperAgers" were used to quantify densities of human leukocyte antigen-D related (HLA-DR)-positive activated microglia underlying five cortical regions. Statistical findings showed a significant main effect of group on differences in microglia density where cognitively normal old showed highest densities. No difference between SuperAgers and young specimens were detected. In two autopsied SuperAgers with MRI FLAIR scans available, prominent hyperintensities in periventricular regions were observed, and interestingly, examination of corresponding postmortem sections showed only sparse microglia densities. In conclusion, activated microglia appear to respond to age-related pathologic changes in cortical white matter, and this phenomenon is largely spared in SuperAgers. Findings offer insights into the relationship between white matter neuroinflammatory changes and cognitive integrity during aging.
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