Evidence map›Paper›PMID 31139071›Full record

ArticleFrontiers in synaptic neuroscience2019

Major Contribution of Somatostatin-Expressing Interneurons and Cannabinoid Receptors to Increased GABA Synaptic Activity in the Striatum of Huntington's Disease Mice.

Sandra M Holley, Laurie Galvan, Talia Kamdjou, Ashley Dong, Michael S Levine, Carlos Cepeda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in synaptic neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington's disease mice and innervate the striatum.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  6. Dysregulation of the Basal Ganglia Indirect Pathway in Early SymptomaticThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  7. Review
  8. Synaptic Dysfunction in Huntington's Disease: Lessons from Genetic Animal Models.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022
    Article
  9. A Brief History and the Significance of the GABACurrent topics in behavioral neurosciences · 2022
    Article
  10. GABACurrent topics in behavioral neurosciences · 2022
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. A Guide to Targeting the Endocannabinoid System in Drug Design.International journal of molecular sciences · 2020
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sandra M HolleyIntellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States.
Laurie GalvanIntellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States.
Talia KamdjouIntellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States.
Ashley DongIntellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States.
Michael S LevineIntellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States.
Carlos CepedaIntellectual and Developmental Disabilities Research Center, Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · US

Funding

UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
NICHD NIH HHS U54 HD087101
6 · The paper itself

Abstract

Huntington's disease (HD) is a heritable neurological disorder that affects cognitive and motor performance in patients carrying the mutated

Indexed as

CB1 receptorselectrophysiologyGABA interneuronsHuntington’s disease (HD)optogeneticsstriatum

Identifiers

PMID31139071
PMCPMC6527892
OpenAlexW2945597205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.