Evidence map›Paper›PMID 31139047›Full record

ArticleFrontiers in neuroscience2019

Non-invasive Motor Cortex Neuromodulation Reduces Secondary Hyperalgesia and Enhances Activation of the Descending Pain Modulatory Network.

Timothy J Meeker, Michael L Keaser, Shariq A Khan, Rao P Gullapalli, David A Seminowicz, Joel D Greenspan

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06640634 (Effect of Anodal Transcranial Direct Current Stimulation on Postdural Puncture Headache), which is not on this map. Cited by 46 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 7 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06640634 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of Anodal Transcranial Direct Current Stimulation on Postdural Puncture Headache: Results of Two Randomized Sham - Controlled Trials

TypeinterventionalSponsorNeuromed IRCCSRan2022 to 2024Enrolled97ConditionsPostdural Puncture Headache, Lumbar PunctureArmsactive in therapeutic tDCS (Th-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS), sham in therapeutic tDCS (Th-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS), active in preventive tDCS (Pr-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS), sham in preventive tDCS (Pr-tDCS): anodal transcranial Direct Current Stimulation (a-tDCS)
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 7 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Efficacy of neuromodulation and rehabilitation approaches on pain relief in patients with spinal cord injury: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  2. Brain modulatory effects of rehabilitation interventions in fibromyalgia: a systematic review of magnetic resonance imaging studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
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  12. Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia.Neuromodulation : journal of the International Neuromodulation Society · 2023
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  20. Interventional neuromodulation techniques for cervicogenic headache.Journal of anesthesia and translational medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Timothy J MeekerDepartment of Neurosurgery, Johns Hopkins Medicine, Baltimore, MD, United States.
Michael L KeaserDepartment of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, Baltimore, MD, United States.
Shariq A KhanDepartment of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, Baltimore, MD, United States.
Rao P GullapalliProgram in Neuroscience, University of Maryland, Baltimore, Baltimore, MD, United States.
David A SeminowiczDepartment of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, Baltimore, MD, United States.
Joel D GreenspanDepartment of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, Baltimore, MD, United States.
University of Maryland, Baltimore · USJohns Hopkins Medicine · US

Funding

TRAINING IN OROFACIAL BIOLOGY AND NEUROSCIENCET32DE007309 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI GORDON, SHARON M. · 1997 to 2012
$6.8M
Training Program in NeuroscienceT32NS063391 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI Jessica Aurora Mong · 2008 to 2026
$4.0M
Behaviors related to Human Neural Activity during Experimental Vigilance to PainR01NS107602 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LENZ, FRED · 2018 to 2022
$3.1M
NIDCR NIH HHS T32 DE007309NINDS NIH HHS R01 NS107602NINDS NIH HHS T32 NS063391
6 · The paper itself

Abstract

Central sensitization is a driving mechanism in many chronic pain patients, and manifests as hyperalgesia and allodynia beyond any apparent injury. Recent studies have demonstrated analgesic effects of motor cortex (M1) stimulation in several chronic pain disorders, yet its neural mechanisms remain uncertain. We evaluated whether anodal M1 transcranial direct current stimulation (tDCS) would mitigate central sensitization as measured by indices of secondary hyperalgesia. We used a capsaicin-heat pain model to elicit secondary mechanical hyperalgesia in 27 healthy subjects. In an assessor and subject-blind randomized, sham-controlled, crossover trial, anodal M1 tDCS decreased the intensity of pinprick hyperalgesia more than cathodal or sham tDCS. To elucidate the mechanism driving analgesia, subjects underwent fMRI of painful mechanical stimuli prior to and following induction of the pain model, after receiving M1 tDCS. We hypothesized that anodal M1 tDCS would enhance engagement of a descending pain modulatory (DPM) network in response to mechanical stimuli. Anodal tDCS normalized the effects of central sensitization on neurophysiological responses to mechanical pain in the medial prefrontal cortex, pregenual anterior cingulate cortex, and periaqueductal gray, important regions in the DPM network. Taken together, these results provide support for the hypothesis that anodal M1-tDCS reduces central sensitization-induced hyperalgesia through the DPM network in humans.

Indexed as

BOLD fMRIevent-related fMRIhumanmotor cortex neuromodulationpainpain modelsecondary hyperalgesiatranscranial direct current stimulation

Identifiers

PMID31139047
PMCPMC6519323
OpenAlexW2944710348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.