Evidence map›Paper›PMID 31138898›Full record

ArticleActa pharmacologica Sinica2019

Integrating yeast chemical genomics and mammalian cell pathway analysis.

Fu-Lai Zhou, Sheena C Li, Yue Zhu, Wan-Jing Guo, Li-Jun Shao, Justin Nelson, Scott Simpkins, De-Hua Yang, Qing Liu, Yoko Yashiroda and 8 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Special Issue: "Yeast as a Model System to Study Human Diseases".International journal of molecular sciences · 2025
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 3 countries.

Fu-Lai Zhou *The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai, 201203, China.
Sheena C Li *RIKEN Center for Sustainable Resource Science, Wako, Saitama, 3510198, Japan.
Yue ZhuThe National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai, 201203, China.
Wan-Jing GuoThe National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai, 201203, China.
Li-Jun ShaoThe National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai, 201203, China.
Justin NelsonBioinformatics and Computational Biology Program, University of Minnesota-Twin Cities, Minneapolis, Minnesota, 55455, USA.
Scott SimpkinsBioinformatics and Computational Biology Program, University of Minnesota-Twin Cities, Minneapolis, Minnesota, 55455, USA.
De-Hua YangThe National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai, 201203, China.
Qing LiuThe National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai, 201203, China.
Yoko YashirodaRIKEN Center for Sustainable Resource Science, Wako, Saitama, 3510198, Japan.
Jin-Biao XuThe State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Yao-Yue FanThe State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Jian-Min YueThe State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Minoru YoshidaRIKEN Center for Sustainable Resource Science, Wako, Saitama, 3510198, Japan.
Tian XiaDepartment of Electronics and Information Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
Chad L MyersBioinformatics and Computational Biology Program, University of Minnesota-Twin Cities, Minneapolis, Minnesota, 55455, USA. chadm@umn.edu.
Charles BooneRIKEN Center for Sustainable Resource Science, Wako, Saitama, 3510198, Japan. charlie.boone@utoronto.ca.
Ming-Wei WangThe National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai, 201203, China. mwwang@simm.ac.cn.
Shanghai Institute of Materia Medica · CNRIKEN Center for Sustainable Resource Science · JPUniversity of Minnesota · USUniversity of Chinese Academy of Sciences · CNBunkyo University · JPChinese Academy of Sciences · CNHuazhong University of Science and Technology · CNNational Center for Drug Screening · CN

Funding

Mapping the reference genetic network of a eukaryotic cellR01HG005853 · NHGRI · UNIVERSITY OF TORONTO · PI ANDREWS, BRENDA JEAN, BOONE, CHARLES · 2010 to 2025
$7.6M
Methods for large-scale analysis of chemical-genetic interactionsR01HG005084 · NHGRI · UNIVERSITY OF MINNESOTA · PI MYERS, CHAD L · 2010 to 2022
$2.9M
NHGRI NIH HHS R01 HG005084NHGRI NIH HHS R01 HG005853
6 · The paper itself

Abstract

Chemical genomics has been applied extensively to evaluate small molecules that modulate biological processes in Saccharomyces cerevisiae. Here, we use yeast as a surrogate system for studying compounds that are active against metazoan targets. Large-scale chemical-genetic profiling of thousands of synthetic and natural compounds from the Chinese National Compound Library identified those with high-confidence bioprocess target predictions. To discover compounds that have the potential to function like therapeutic agents with known targets, we also analyzed a reference library of approved drugs. Previously uncharacterized compounds with chemical-genetic profiles resembling existing drugs that modulate autophagy and Wnt/β-catenin signal transduction were further examined in mammalian cells, and new modulators with specific modes of action were validated. This analysis exploits yeast as a general platform for predicting compound bioactivity in mammalian cells.

Indexed as

Drug DiscoveryAutophagybeta CateninCorrelation of DataGenetic ProfileGenomicsHEK293 CellsHeLa CellsHumansProof of Concept StudySaccharomyces cerevisiaeSmall Molecule LibrariesWnt Signaling Pathwaybeta CateninSmall Molecule Librariesautophagychemical genomicstubulin cytoskeleton assemblyWnt/β-catenin signaling pathwayyeast

Identifiers

PMID31138898
PMCPMC6786357
OpenAlexW2946966621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.