ArticleBritish journal of cancer2019
Night shift work and risk of breast cancer in women: the Generations Study cohort.
Article in British journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05159141 (The Role of Circadian Rhythm in the Effect of Sleep Intervention on Obesity Prevention in Early Childhood), which is not on this map. Cited by 37 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Circadian Rhythm in the Effect of Sleep Intervention on Obesity Prevention in Early Childhood
Who cites it
37 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Nightshift work and risk of breast and prostate cancer: a systematic review and meta-analysis, 2012-2023.Anales del sistema sanitario de Navarra · 2025Pooled it
- Night shift work and breast cancer risk in healthcare workers: a systematic review and meta-analysis.Occupational medicine (Oxford, England) · 2025Pooled it
- Night shift work and female breast cancer: a two-stage dose-response meta-analysis for the correct risk definition.BMC public health · 2024Pooled it
- Night-shift work, breast cancer incidence, and all-cause mortality: an updated meta-analysis of prospective cohort studies.Sleep & breathing = Schlaf & Atmung · 2022Pooled it
- Night-shift work duration and breast cancer risk: an updated systematic review and meta-analysis.BMC women's health · 2021Pooled it
- Association Between Night-Shift Work and Cancer Risk: Updated Systematic Review and Meta-Analysis.Frontiers in oncology · 2020Pooled it
- Night shift work and breast cancer risk: A cohort study based on payroll and survey data from Finland.Scandinavian journal of work, environment & health · 2026Article
- Circadian Rhythms in Cancer: Mechanistic Insights, Chronotherapeutic Strategies, and Translational Challenges.Annals of surgical oncology · 2026Review
- Night shift work and breast cancer: from etiopathology to precision risk analysis.NPJ breast cancer · 2025Review
- A narrative review of sleep and breast cancer: from epidemiology to mechanisms.Cancer causes & control : CCC · 2025Review
- CirRFKB: A knowledgebase of circadian-related risk factors for cancer pathogenesis and personalized medicine.Computational and structural biotechnology journal · 2025Article
- Night shift-induced circadian disruption: links to initiation of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and risk of hepatic cancer.Hepatoma research · 2024Article
- When Do Tumours Develop? Neoplastic Processes Across Different Timescales: Age, Season and Round the Circadian Clock.Evolutionary applications · 2024Review
- Disruption of the intestinal clock drives dysbiosis and impaired barrier function in colorectal cancer.Science advances · 2024Article
- Unveiling the Protective Role of Melatonin in Osteosarcoma: Current Knowledge and Limitations.Biomolecules · 2024Review
- The circadian clock, aging and its implications in cancer.Neoplasia (New York, N.Y.) · 2023Article
- Consequences of Shift Work and Night Work: A Literature Review.Healthcare (Basel, Switzerland) · 2023Review
- Circadian clocks in health and disease: Dissecting the roles of the biological pacemaker in cancer.F1000Research · 2023Review
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is plausible that night shift work could affect breast cancer risk, possibly by melatonin suppression or circadian clock disruption, but epidemiological evidence is inconclusive.
methodsUsing serial questionnaires from the Generations Study cohort, we estimated hazard ratios (HR) and 95% confidence intervals (95%CI) for breast cancer in relation to being a night shift worker within the last 10 years, adjusted for potential confounders.
resultsAmong 102,869 women recruited in 2003-2014, median follow-up 9.5 years, 2059 developed invasive breast cancer. The HR in relation to night shift work was 1.00 (95%CI: 0.86-1.15). There was a significant trend with average hours of night work per week (P = 0.035), but no significantly raised risks for hours worked per night, nights worked per week, average hours worked per week, cumulative years of employment, cumulative hours, time since cessation, type of occupation, age starting night shift work, or age starting in relation to first pregnancy.
conclusionsThe lack of overall association, and no association with all but one measure of dose, duration, and intensity in our data, does not support an increased risk of breast cancer from night shift work in women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.