ArticleMolecular psychiatry2021
The neuroinflammatory component of negative affect in patients with chronic pain.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Comparative effectiveness of non-pharmacological interventions for depression and anxiety in chronic low back pain: a Bayesian network meta-analysis of randomized controlled trials.Frontiers in public health · 2026Pooled it
- The potential impact of exercise on affect and neuroinflammation in older adults living with fibromyalgia: a scoping review.Frontiers in human neuroscience · 2024Pooled it
- The core of maintaining neuropathic pain: Crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord).Brain and behavior · 2023Pooled it
- Neural correlates of co-occurring pain and depression: an activation-likelihood estimation (ALE) meta-analysis and systematic review.Translational psychiatry · 2022Pooled it
- Multimodal approach to identify neuropsychophysiological subgroups in myalgic encephalomyelitis/chronic fatigue syndrome and their relevance for rehabilitation: protocol for a mechanistic cross-sectional and longitudinal study.Brain, behavior, & immunity - health · 2026Article
- Towards a Whole-Body Assessment of Pain Using the 18 kDa Translocator Protein (TSPO) as a Broad-Spectrum Imaging Marker of Inflammation.European journal of pain (London, England) · 2026Review
- Network-based disease fingerprinting with neuroinflammation PET imaging.Journal of neuroinflammation · 2026Article
- Brain-immune correlates of quality of life in adolescents with chronic musculoskeletal pain.Brain, behavior, and immunity · 2026Article
- MASSAG model: Towards an integrative neuroscience framework linking emotional trauma, pain, and mechanisms of force-based manipulations.Neuroscience and biobehavioral reviews · 2026Review
- Microglial Activation in Nociplastic Pain: From Preclinical Models to PET Neuroimaging and Implications for Targeted Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Article
- Network-based disease fingerprinting with neuroinflammation PET imaging.Research square · 2025Article
- Trigeminal nerve microstructure is linked with neuroinflammation and brainstem activity in migraine.Brain : a journal of neurology · 2025Article
- Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies-A Narrative Review.International journal of molecular sciences · 2025Review
- Neuroinflammation at the Neuroforamina and Spinal Cord in Patients with Painful Cervical Radiculopathy and Pain-Free Participants: An [Journal of clinical medicine · 2025Article
- Neuroplasticity in chronic pain: insights into diagnosis and treatment.The Korean journal of pain · 2025Article
- The Intersection of Rurality, Unmet Treatment Need, and Cannabis Use for Adults with Chronic Pain.Cannabis (Albuquerque, N.M.) · 2025Article
- 18 kDa Translocator protein (TSPO) is upregulated in rat brain after peripheral nerve injury and downregulated by diroximel fumarate.Brain, behavior, and immunity · 2025Article
- Review
- Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by [Brain, behavior, and immunity · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is known about the mechanism underlying pain-comorbid NA, previous studies have implicated neuroinflammation in the pathophysiology of both depression and chronic pain. Here, we tested the hypothesis that NA in pain patients is linked to elevations in the brain levels of the glial marker 18 kDa translocator protein (TSPO), and changes in functional connectivity. 25 cLBP patients (42.4 ± 13 years old; 13F, 12M) with chronic low back pain (cLBP) and 27 healthy control subjects (48.9 ± 13 years old; 14F, 13M) received an integrated (i.e., simultaneous) positron emission tomography (PET)/magnetic resonance imaging (MRI) brain scan with the second-generation TSPO ligand [
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.