ArticleScientific reports2019
Time course images of cellular injury and recovery in murine brain with high-resolution GRIN lens system.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
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- Imagining the future of optical microscopy: everything, everywhere, all at once.Communications biology · 2023Review
- Clay Nanotubes Loaded with Diazepam or Xylazine Permeate the Brain through Intranasal Administration in Mice.International journal of molecular sciences · 2023Article
- Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice.Experimental neurology · 2023Article
- The cause of acute lethality of mice exposed to a laser-induced shock wave to the brainstem.Scientific reports · 2022Article
- Review
- Immediate induction of varicosities by transverse compression but not uniaxial stretch in axon mechanosensation.Acta neuropathologica communications · 2022Article
- Through the looking glass: A review of cranial window technology for optical access to the brain.Journal of neuroscience methods · 2021Review
- Rapid and Reversible Development of Axonal Varicosities: A New Form of Neural Plasticity.Frontiers in molecular neuroscience · 2021Review
- Cellular Analysis and Chemotherapeutic Potential of a Bi-Functionalized Halloysite Nanotube.Pharmaceutics · 2020Article
- Low brain endocannabinoids associated with persistent non-goal directed nighttime hyperactivity after traumatic brain injury in mice.Scientific reports · 2020Article
- Longitudinal optical imaging technique to visualize progressive axonal damage after brain injury in mice reveals responses to different minocycline treatments.Scientific reports · 2020Article
- Generation of an Iba1-EGFP Transgenic Rat for the Study of Microglia in an Outbred Rodent Strain.eNeuroArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Time course, in vivo imaging of brain cells is crucial to fully understand the progression of secondary cellular damage and recovery in murine models of injury. We have combined high-resolution gradient index lens technology with a model of diffuse axonal injury in rodents to enable repeated visualization of fine features of individual cells in three-dimensional space over several weeks. For example, we recorded changes in morphology in the same axons in the external capsule numerous times over 30 to 60 days, before and after induced traumatic brain injury. We observed the expansion of secondary injury and limited recovery of individual axons in this subcortical white matter tract over time. In another application, changes in microglial activation state were visualized in the penumbra region of mice before and after ischemia induced by middle carotid artery occlusion. The ability to collect a series of high-resolution images of cellular features of the same cells pre- and post-injury enables a unique opportunity to study the progression of damage, spontaneous healing, and effects of therapeutics in mouse models of neurodegenerative disease and brain injury.
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Registered trials
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