Evidence map›Paper›PMID 31138878›Full record

Observational studyScientific reports2019

Deep Learning Convolutional Neural Networks for the Automatic Quantification of Muscle Fat Infiltration Following Whiplash Injury.

Kenneth A Weber, Andrew C Smith, Marie Wasielewski, Kamran Eghtesad, Pranav A Upadhyayula, Max Wintermark, Trevor J Hastie, Todd B Parrish, Sean Mackey, James M Elliott

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Artificial Intelligence in Spine and Paraspinal Muscle Analysis.Advances in experimental medicine and biology · 2024
    Review
  11. Biopsychosocial sequelae and recovery trajectories from whiplash injury following a motor vehicle collision.The spine journal : official journal of the North American Spine Society · 2023
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Analysis of the paraspinal muscle morphology of the lumbar spine using a convolutional neural network (CNN).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Kenneth A WeberSystems Neuroscience and Pain Lab, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA, USA. kenweber@stanford.edu.ORCID http://orcid.org/0000-0002-0916-9174
Andrew C SmithSchool of Physical Therapy, Regis University, Denver, CO, USA.
Marie WasielewskiDepartment of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Kamran EghtesadSystems Neuroscience and Pain Lab, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA, USA.
Pranav A UpadhyayulaSystems Neuroscience and Pain Lab, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA, USA.
Max WintermarkDepartment of Radiology, Neuroradiology Section, Stanford University, Palo Alto, CA, USA.
Trevor J HastieStatistics Department, Stanford University, Palo Alto, CA, USA.
Todd B ParrishDepartment of Radiology, Northwestern University, Chicago, IL, USA.
Sean MackeySystems Neuroscience and Pain Lab, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA, USA.
James M ElliottDepartment of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Center for Pain and the Brain · USNorthwestern University · USPalo Alto University · USRegis University · USStanford Medicine · USStanford University · US

Funding

Interdisciplinary Research Training in Pain and Substance Use DisordersT32DA035165 · NIDA · STANFORD UNIVERSITY · PI SEAN C MACKEY · 2013 to 2026
$7.2M
Neuroimaging and Mentoring in Translational Pain ResearchK24DA029262 · NIDA · STANFORD UNIVERSITY · PI MACKEY, SEAN C · 2010 to 2019
$1.9M
Neuromuscular Mechanisms Underlying Poor Recovery from Whiplash InjuriesR01HD079076 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI COURTNEY, D. MARK, ELLIOTT, JAMES MATTHEW · 2014 to 2018
$1.6M
Neuroimaging-Based Brain and Spinal Cord Biomarkers for Cervical RadiculopathyK23NS104211 · NINDS · STANFORD UNIVERSITY · PI WEBER, KENNETH ARNOLD · 2018 to 2022
$875k
MRI and machine learning to improve early prognosis and clinical management after spinal cord injuryR03HD094577 · NICHD · UNIVERSITY OF COLORADO DENVER · PI SMITH, ANDREW CRAIG · 2019 to 2020
$195k
NICHD NIH HHS R01 HD079076NICHD NIH HHS R03 HD094577NIDA NIH HHS K24 DA029262NIDA NIH HHS T32 DA035165NINDS NIH HHS K23 NS104211
6 · The paper itself

Abstract

Muscle fat infiltration (MFI) of the deep cervical spine extensors has been observed in cervical spine conditions using time-consuming and rater-dependent manual techniques. Deep learning convolutional neural network (CNN) models have demonstrated state-of-the-art performance in segmentation tasks. Here, we train and test a CNN for muscle segmentation and automatic MFI calculation using high-resolution fat-water images from 39 participants (26 female, average = 31.7 ± 9.3 years) 3 months post whiplash injury. First, we demonstrate high test reliability and accuracy of the CNN compared to manual segmentation. Then we explore the relationships between CNN muscle volume, CNN MFI, and clinical measures of pain and neck-related disability. Across all participants, we demonstrate that CNN muscle volume was negatively correlated to pain (R = -0.415, p = 0.006) and disability (R = -0.286, p = 0.045), while CNN MFI tended to be positively correlated to disability (R = 0.214, p = 0.105). Additionally, CNN MFI was higher in participants with persisting pain and disability (p = 0.049). Overall, CNN's may improve the efficiency and objectivity of muscle measures allowing for the quantitative monitoring of muscle properties in disorders of and beyond the cervical spine.

Indexed as

Neural Networks, ComputerAdipose TissueAdultFemaleHumansImage Processing, Computer-AssistedLongitudinal StudiesMagnetic Resonance ImagingMaleMuscle, SkeletalNeckPainReproducibility of ResultsSpectrum AnalysisSpineWaterWater

Identifiers

PMID31138878
PMCPMC6538618
OpenAlexW2947399947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.