Evidence map›Paper›PMID 31138854›Full record

ArticleScientific reports2019

Permutation Statistics for Connectivity Analysis between Regions of Interest in EEG and MEG Data.

Fahimeh Mamashli, Matti Hämäläinen, Jyrki Ahveninen, Tal Kenet, Sheraz Khan

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
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  3. Article
  4. Article
  5. Review
  6. Characterizing Directional Dynamics of Semantic Prediction Based on Inter-regional Temporal Generalization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fahimeh MamashliDepartment of Neurology, MGH, Harvard Medical School, Boston, MA, USA. fmamashli@mgh.harvard.edu.
Matti HämäläinenAthinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Boston, MA, USA.
Jyrki AhveninenAthinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Boston, MA, USA.
Tal KenetDepartment of Neurology, MGH, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3346-9027
Sheraz KhanAthinoula A. Martinos Center for Biomedical Imaging, MGH/HST, Boston, MA, USA. sheraz@nmr.mgh.harvard.edu.

Funding

Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Device-Independent Acquisition and Real Time Spatiotemporal Analysis of Clinical Electrophysiology DataU01EB023820 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI MOSHER, JOHN COMPTON, OKADA, YOSHIO · 2017 to 2021
$5.8M
Scalable Software for Distributed Processing and Visualization of Multi-Site MEG/EEG DatasetsR01NS104585 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MATTI HAMALAINEN · 2018 to 2026
$4.3M
Functional connectivity substrates of social and non-social deficits in ASDR01HD073254 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI KENET, TAL · 2013 to 2017
$3.4M
Decoding parametric attributes of auditory working memories from human brain activityR01DC016915 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI AHVENINEN, JYRKI · 2018 to 2022
$3.0M
Non-invasive measures of multisensory cortical feedforward and feedback influencesR01DC016765 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI AHLFORS, SEPPO PENTTI, AHVENINEN, JYRKI · 2018 to 2022
$2.7M
A Storage Area Network for Structural and Functional Image AnalysisS10RR023401 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2009 to 2009
$2.0M
A Siemens MAGNETOTOM Trio 3 Tesla MRI SystemS10RR021110 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2006 to 2006
$500k
306 CHANNEL MEG INSTRUMENTS10RR014798 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BELLIVEAU, JOHN W · 2000 to 2000
$500k
Computeserver Structural &Functional Image AnalysisS10RR019307 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2004 to 2004
$496k
NCRR NIH HHS S10 RR014798NCRR NIH HHS S10 RR019307NCRR NIH HHS S10 RR021110NCRR NIH HHS S10 RR023401NIBIB NIH HHS P41 EB015896NIBIB NIH HHS U01 EB023820NICHD NIH HHS R01 HD073254NIDCD NIH HHS R01 DC016765NIDCD NIH HHS R01 DC016915NINDS NIH HHS R01 NS104585
6 · The paper itself

Abstract

Connectivity estimates based on electroencephalography (EEG) and magnetoencephalography (MEG) are unique in their ability to provide neurophysiologically meaningful spectral and temporal information non-invasively. This multi-dimensional aspect of the MEG/EEG based connectivity increases the challenges of the analysis and interpretation of the data. Many MEG/EEG studies address this complexity by using a hypothesis-driven approach, which focuses on particular regions of interest (ROI). However, if an effect is distributed unevenly over a large ROI and variable across subjects, it may not be detectable using conventional methods. Here, we propose a novel approach, which enhances the statistical power for weak and spatially discontinuous effects. This results in the ability to identify statistically significant connectivity patterns with spectral, temporal, and spatial specificity while correcting for multiple comparisons using nonparametric permutation methods. We call this new approach the Permutation Statistics for Connectivity Analysis between ROI (PeSCAR). We demonstrate the processing steps with simulated and real human data. The open-source Matlab code implementing PeSCAR are provided online.

Indexed as

Models, NeurologicalAdultBrainBrain MappingElectroencephalographyHealthy VolunteersHumansMagnetoencephalographyNeural PathwaysSignal-To-Noise Ratio

Identifiers

PMID31138854
PMCPMC6538606

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.