Evidence map›Paper›PMID 31138840›Full record

ArticleScientific reports2019

Cynomolgus macaque IL37 polymorphism and control of SIV infection.

Takashi Shiina, Shingo Suzuki, Nicolas Congy-Jolivet, Alice Aarnink, Henri-Jean Garchon, Nathalie Dereuddre-Bosquet, Bruno Vaslin, Nicolas Tchitchek, Delphine Desjardins, Brigitte Autran and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Takashi ShiinaDepartment of Molecular Life Sciences, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Shingo SuzukiDepartment of Molecular Life Sciences, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.
Nicolas Congy-JolivetLaboratoire d'immunogénétique moléculaire (LIMT, EA 3034, Faculté de médecine Purpan, Université Toulouse 3, Paul Sabatier, UPS), Toulouse, France.
Alice AarninkLaboratoire d'immunogénétique moléculaire (LIMT, EA 3034, Faculté de médecine Purpan, Université Toulouse 3, Paul Sabatier, UPS), Toulouse, France.
Henri-Jean GarchonInserm U1173, Simone Veil School of Health Sciences, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.
Nathalie Dereuddre-BosquetCEA - Université Paris-Sud 11 - INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT Department, IBFJ, 92265, Fontenay-aux-Roses, France.
Bruno VaslinCEA - Université Paris-Sud 11 - INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT Department, IBFJ, 92265, Fontenay-aux-Roses, France.
Nicolas TchitchekCEA - Université Paris-Sud 11 - INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT Department, IBFJ, 92265, Fontenay-aux-Roses, France.
Delphine DesjardinsCEA - Université Paris-Sud 11 - INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT Department, IBFJ, 92265, Fontenay-aux-Roses, France.ORCID http://orcid.org/0000-0002-5820-3914
Brigitte AutranU1135, CIMI, INSERM, Paris, France, Sorbonne Universités, UPMC Université Paris 06, Paris, France, Département d'Immunologie, Hôpital Pitié-Salpêtrière, AP-HP, Paris, France.
Olivier LambotteCEA - Université Paris-Sud 11 - INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT Department, IBFJ, 92265, Fontenay-aux-Roses, France.
Ioannis TheodorouCenter for Immunology and Infectious Diseases, INSERM UMR S 1135, Pierre et Marie Curie University, Paris, France.
Roger Le GrandCEA - Université Paris-Sud 11 - INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT Department, IBFJ, 92265, Fontenay-aux-Roses, France.
Antoine BlancherLaboratoire d'immunogénétique moléculaire (LIMT, EA 3034, Faculté de médecine Purpan, Université Toulouse 3, Paul Sabatier, UPS), Toulouse, France. blancher.antoine@neuf.fr.
Université Paris-Sud · FRInserm · FRTokai University · JPUniversité Toulouse III - Paul Sabatier · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association between gene polymorphisms and plasma virus load at the set point (SP-PVL) was investigated in Mauritian macaques inoculated with SIV. Among 44 macaques inoculated with 50 AID50, six individuals were selected: three with SP-PVL among the highest and three with SP-PVL among the lowest. The exons of 390 candidate genes of these six animals were sequenced. Twelve non-synonymous single nucleotide polymorphisms (NS-SNPs) lying in nine genes potentially associated with PVL were genotyped in 23 animals. Three NS-SNPs with probabilities of association with PVL less than 0.05 were genotyped in a total of 44 animals. One NS-SNP lying in exon 1 of the IL37 gene displayed a significant association (p = 3.33 × 10

Indexed as

Polymorphism, Single NucleotideAnimalsBase SequenceExonsGene ExpressionGenetic LociHaplotypesHigh-Throughput Nucleotide SequencingHistocompatibility Antigens Class IHost-Pathogen InteractionsInterferon-Stimulated Gene Factor 3, gamma SubunitInterleukin-1Linear ModelsMacaca fascicularisMaleOdds RatioHistocompatibility Antigens Class IInterferon-Stimulated Gene Factor 3, gamma SubunitInterleukin-1

Identifiers

PMID31138840
PMCPMC6538695
OpenAlexW2946980448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.