Evidence map›Paper›PMID 31138803›Full record

ArticleNature communications2019

Interspecies conservation of organisation and function between nonhomologous regional centromeres.

Pin Tong, Alison L Pidoux, Nicholas R T Toda, Ryan Ard, Harald Berger, Manu Shukla, Jesus Torres-Garcia, Carolin A Müller, Conrad A Nieduszynski, Robin C Allshire

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
8.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Chromosome segregation synchrony inbioRxiv : the preprint server for biology · 2026
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  10. TheeLife · 2022
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Pin TongWellcome Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh, EH9 3BF, UK.
Alison L PidouxWellcome Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh, EH9 3BF, UK. alison.pidoux@ed.ac.uk.
Nicholas R T TodaWellcome Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh, EH9 3BF, UK.
Ryan ArdWellcome Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh, EH9 3BF, UK.ORCID http://orcid.org/0000-0002-9070-9747
Harald BergerWellcome Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh, EH9 3BF, UK.
Manu ShuklaWellcome Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh, EH9 3BF, UK.
Jesus Torres-GarciaWellcome Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh, EH9 3BF, UK.ORCID http://orcid.org/0000-0003-1029-8325
Carolin A MüllerSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.ORCID http://orcid.org/0000-0002-7422-5582
Conrad A NieduszynskiSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.ORCID http://orcid.org/0000-0003-2001-076X
Robin C AllshireWellcome Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh, EH9 3BF, UK. robin.allshire@ed.ac.uk.ORCID http://orcid.org/0000-0002-8005-3625
Wellcome Centre for Cell Biology · GBUniversity of Oxford · GBCentre National de la Recherche Scientifique · FRUniversity of Copenhagen · DK

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9M
NCI NIH HHS P30 CA045508Wellcome Trust 200885/Z/16/Z
6 · The paper itself

Abstract

Despite the conserved essential function of centromeres, centromeric DNA itself is not conserved. The histone-H3 variant, CENP-A, is the epigenetic mark that specifies centromere identity. Paradoxically, CENP-A normally assembles on particular sequences at specific genomic locations. To gain insight into the specification of complex centromeres, here we take an evolutionary approach, fully assembling genomes and centromeres of related fission yeasts. Centromere domain organization, but not sequence, is conserved between Schizosaccharomyces pombe, S. octosporus and S. cryophilus with a central CENP-A

Indexed as

CentromereCentromere Protein AChromatinChromatin Assembly and DisassemblyChromosomal Proteins, Non-HistoneConserved SequenceDNAEpigenesis, GeneticHistonesKinetochoresRNA, Ribosomal, 5SRNA, TransferSchizosaccharomycesSchizosaccharomyces pombe ProteinsSyntenyCentromere Protein AChromatinChromosomal Proteins, Non-HistoneCnp1 protein, S pombeDNAHistonesRNA, Ribosomal, 5SRNA, TransferSchizosaccharomyces pombe Proteins

Identifiers

PMID31138803
PMCPMC6538654
OpenAlexW2951924217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.