Evidence map›Paper›PMID 31138744›Full record

ArticlemBio2019

A Stress Response Monitoring Lipoprotein Trafficking to the Outer Membrane.

Kerrie L May, Kelly M Lehman, Angela M Mitchell, Marcin Grabowicz

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 76 citations in OpenAlex.

  1. ThemBio · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. ThemBio · 2026
    Article
  7. Article
  8. Article
  9. Novel Antibacterial Approaches and Therapeutic Strategies.Antibiotics (Basel, Switzerland) · 2025
    Review
  10. The BfmRS stress response protectsJournal of bacteriology · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Essential role ofInfection and immunity · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kerrie L MayEmory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Kelly M LehmanEmory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Angela M MitchellDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.ORCID 0000-0003-1062-0716
Marcin GrabowiczEmory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA marcin.grabowicz@emory.edu.ORCID 0000-0001-8000-2222
Emory University · USPrinceton University · US

Funding

Biogenesis and maintenance of the outer membrane of Gram-negative bacteriaR35GM118024 · NIGMS · PRINCETON UNIVERSITY · PI SILHAVY, THOMAS J. · 2016 to 2025
$8.1M
NIGMS NIH HHS R35 GM118024
6 · The paper itself

Abstract

Gram-negative bacteria produce lipid-anchored lipoproteins that are trafficked to their outer membrane (OM). These lipoproteins are essential components in each of the molecular machines that build the OM, including the Bam machine that assembles β-barrel proteins and the Lpt pathway that transports lipopolysaccharide. Stress responses are known to monitor Bam and Lpt function, yet no stress system has been found that oversees the fundamental process of lipoprotein trafficking. We used genetic and chemical biology approaches to induce several different lipoprotein trafficking stresses in

Indexed as

Signal TransductionStress, PhysiologicalBacterial Outer Membrane ProteinsCopperEscherichia coliEscherichia coli ProteinsLipoproteinsProtein TransportBacterial Outer Membrane ProteinsCopperEscherichia coli ProteinsLipoproteinsNlpE protein, E colicopperCpx responseenvelope stress responselipoproteinsLol pathwayNlpEouter membrane

Identifiers

PMID31138744
PMCPMC6538781
OpenAlexW2946227811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.