Evidence map›Paper›PMID 31138707›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Analysis of phototoxin taste closely correlates nucleophilicity to type 1 phototoxicity.

Eun Jo Du, Tae Jung Ahn, Hwajin Sung, HyunJi Jo, Hyung-Wook Kim, Seong-Tae Kim, KyeongJin Kang

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. eLife · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Eun Jo DuDepartment of Anatomy and Cell Biology, School of Medicine, Sungkyunkwan University, 16419 Suwon, Republic of Korea.
Tae Jung AhnDepartment of Anatomy and Cell Biology, School of Medicine, Sungkyunkwan University, 16419 Suwon, Republic of Korea.
Hwajin SungDepartment of Anatomy and Cell Biology, School of Medicine, Sungkyunkwan University, 16419 Suwon, Republic of Korea.
HyunJi JoDepartment of Anatomy and Cell Biology, School of Medicine, Sungkyunkwan University, 16419 Suwon, Republic of Korea.
Hyung-Wook KimCollege of Life Sciences, Sejong University, 04519 Seoul, Republic of Korea.
Seong-Tae KimDepartment of Molecular Cell Biology, School of Medicine, Sungkyunkwan University, 16419 Suwon, Republic of Korea.
KyeongJin KangDepartment of Anatomy and Cell Biology, School of Medicine, Sungkyunkwan University, 16419 Suwon, Republic of Korea; kangk@skku.edu.ORCID 0000-0003-0446-469X
Sungkyunkwan University · KRSamsung Medical Center · KRSejong University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pigments often inflict tissue-damaging and proaging toxicity on light illumination by generating free radicals and reactive oxygen species (ROS). However, the molecular mechanism by which organisms sense phototoxic pigments is unknown. Here, we discover that Transient Receptor Potential Ankyrin 1-A isoform [TRPA1(A)], previously shown to serve as a receptor for free radicals and ROS induced by photochemical reactions, enables

Indexed as

AnimalsAnophelesDermatitis, PhototoxicDrosophila melanogasterDrosophila ProteinsFree RadicalsIon ChannelsOocytesPigments, BiologicalProtein IsoformsReactive Oxygen SpeciesTasteXenopus laevisDrosophila ProteinsFree RadicalsIon ChannelsPigments, BiologicalProtein IsoformsReactive Oxygen SpeciesTrpA1 protein, Drosophilachemosensationnucleophilephotochemistrytype 1 phototoxins

Identifiers

PMID31138707
PMCPMC6575569
OpenAlexW2947160641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.