ArticleProceedings of the National Academy of Sciences of the United States of America2019
The long noncoding RNA
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
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Who cites it
40 citing papers in PubMed, 62 citations in OpenAlex.
- The dynamic interplay between viruses and host non-coding RNA species.FEMS microbiology reviews · 2026Review
- Article
- Disruption of Morrbid alleviates autoinflammatory osteomyelitis in Pstpip2-deficient mice.Disease models & mechanisms · 2025Article
- An Emphasis on the Role of Long Non-Coding RNAs in Viral Gene Expression, Pathogenesis, and Innate Immunity in Viral Chicken Diseases.Non-coding RNA · 2025Review
- Biological functions and affected signaling pathways by Long Non-Coding RNAs in the immune system.Non-coding RNA research · 2025Review
- Epigenetic control of tissue resident memory T cells.Frontiers in immunology · 2025Review
- Review
- Transcription regulation by long non-coding RNAs: mechanisms and disease relevance.Nature reviews. Molecular cell biology · 2024Review
- RNA sequencing reveals differential long noncoding RNA expression profiles in bacterial and viral meningitis in children.BMC medical genomics · 2024Article
- Biological Roles and Pathogenic Mechanisms of LncRNA MIR4435-2HG in Cancer: A Comprehensive Review.Current issues in molecular biology · 2023Review
- RNA circuits and RNA-binding proteins in T cells.Trends in immunology · 2023Review
- Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation.Nature communications · 2023Article
- Recent insights into the role of Akt in CD4 T-cell activation and differentiation: alternative splicing and beyond.Immunometabolism (Cobham, Surrey) · 2023Review
- Regulation of T cell differentiation and function by long noncoding RNAs in homeostasis and cancer.Frontiers in immunology · 2023Review
- From thymus to tissues and tumors: A review of T-cell biology.The Journal of allergy and clinical immunology · 2023Review
- A New Long Noncoding RNA, MAHAT, Inhibits Replication of Porcine Reproductive and Respiratory Syndrome Virus by Recruiting DDX6 To Bind toJournal of virology · 2022Article
- Long Noncoding RNA MIR4435-2HG Suppresses Colorectal Cancer Initiation and Progression By Reprogramming Neutrophils.Cancer immunology research · 2022Article
- The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression.The Journal of experimental medicine · 2022Article
- LNCing RNA to immunity.Trends in immunology · 2022Review
- Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and Memory.Cold Spring Harbor perspectives in biology · 2022Review
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 2 countries.
Jonathan J KotzinDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Fany IsekaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Jasmine WrightDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Megha G BasavappaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Megan L ClarkDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Mohammed-Alkhatim AliInstitute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Mohamed S Abdel-HakeemInstitute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0003-0226-3464
Tanner F RobertsonDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Walter K MowelDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Leonel JoannasDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Vanessa D NealDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Sean P SpencerDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Camille M SyrettInstitute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Montserrat C AngueraInstitute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Adam WilliamsDepartment of Genetics and Genome Sciences, The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032.
E John WherryInstitute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Jorge Henao-MejiaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; jhena@pennmedicine.upenn.edu.
University of Pennsylvania · USParker Institute for Cancer Immunotherapy · USCairo University · EGChildren's Hospital of Philadelphia · USJackson Laboratory · US
Funding
Virology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI GEORG Michael LAUER · 2009 to 2026
$48.1MSynergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Dario AA Vignali · 2015 to 2026
$30.8MSequencing and Viral Evolution CoreU19AI117950 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WHERRY, E. JOHN · 2015 to 2019
$12.0MRadiation and checkpoint blockade for cancer immune therapyP01CA210944 · NCI · UNIVERSITY OF PENNSYLVANIA · PI VONDERHEIDE, ROBERT H · 2017 to 2022
$11.5MTraining Program in Investigative HepatologyT32DK007356 · NIDDK · YALE UNIVERSITY · PI MICHAEL H NATHANSON · 1986 to 2026
$7.4MHEMATOPOIESIS TRAINING GRANTT32DK007780 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI TONG, WEI · 1999 to 2023
$6.7MVMD-PhD Training in Infectious Disease-Related ResearchT32AI070077 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Michael Lee Atchison · 2008 to 2026
$3.5MRegulation of short-lived myeloid cells by the novel long non-coding RNA MorrbidR01HL136572 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HENAO-MEJIA, JORGE · 2017 to 2021
$2.0MCellular and transcriptional control of exhausted CD8 T cells lineage dynamicsR01AI105343 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WHERRY, E. JOHN · 2014 to 2017
$1.6MRegulation of adipose tissue inflammation by the miR-181 familyR21DK111755 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI HENAO-MEJIA, JORGE · 2016 to 2018
$604kThe Function of lncRNAs in Airway Epithelial CellsR21AI133440 · NIAID · JACKSON LABORATORY · PI WILLIAMS, ADAM · 2018 to 2019
$520kThe Role of the lncRNA MORRBID in Controlling Dendritic Cell Lifespan and Adaptive ImmunityR21AI135221 · NIAID · JACKSON LABORATORY · PI WILLIAMS, ADAM · 2018 to 2019
$520kNCI NIH HHS P01 CA210944NHLBI NIH HHS F30 HL138739NHLBI NIH HHS R01 HL136572NIAID NIH HHS F31 AI124538NIAID NIH HHS P01 AI108545NIAID NIH HHS R01 AI105343NIAID NIH HHS R21 AI128060NIAID NIH HHS R21 AI133440NIAID NIH HHS R21 AI135221NIAID NIH HHS T32 AI070077NIAID NIH HHS U19 AI082630NIAID NIH HHS U19 AI117950NIDDK NIH HHS F30 DK094708NIDDK NIH HHS R21 DK111755NIDDK NIH HHS T32 DK007356NIDDK NIH HHS T32 DK007780
Abstract
The transcriptional programs that regulate CD8 T-cell differentiation and function in the context of viral infections or tumor immune surveillance have been extensively studied; yet how long noncoding RNAs (lncRNAs) and the loci that transcribe them contribute to the regulation of CD8 T cells during viral infections remains largely unexplored. Here, we report that transcription of the lncRNA
Indexed as
AnimalsCD8-Positive T-LymphocytesCell DifferentiationInterferon Type ILymphocyte ActivationLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMaleMiceMice, Inbred C57BLMice, TransgenicPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-bcl-2Receptors, Antigen, T-CellRNA, Long NoncodingSignal TransductionInterferon Type IPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-bcl-2Receptors, Antigen, T-CellRNA, Long NoncodingCD8 T cellslncRNAsviral infection
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.