ArticleProceedings of the National Academy of Sciences of the United States of America2019
High sensitivity and interindividual variability in the response of the human circadian system to evening light.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 210 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
210 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Ocular light and optical radiation exposure as a modifiable environmental determinant of health: expert consensus on research gaps and priorities.BMC medicine · 2026Guideline
- Associations between systemic melatonin and human myopia: A systematic review.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023Pooled it
- Trial
- Effects of chronotype-tailored bright light intervention on post-treatment symptoms and quality of life in breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Trial
- Melatonin suppression does not automatically alter sleepiness, vigilance, sensory processing, or sleep.Sleep · 2022Trial
- The Effect of Exogenous Melatonin on Eating Habits of Female Night Workers with Excessive Weight.Nutrients · 2022Trial
- Trial
- Evening light environments can be designed to consolidate and increase the duration of REM-sleep.Scientific reports · 2022Trial
- Home-based light therapy for fatigue following acquired brain injury: a pilot randomized controlled trial.BMC neurology · 2021Trial
- Diurnal rhythms of urine volume and electrolyte excretion in healthy young men under differing intensities of daytime light exposure.Scientific reports · 2021Trial
- The effects of dynamic daylight-like light on the rhythm, cognition, and mood of irregular shift workers in closed environment.Scientific reports · 2021Trial
- Trial
- Impact of Dim Light at Night on Urinary 6-Sulphatoxymelatonin Concentrations and Sleep in Healthy Humans.International journal of molecular sciences · 2020Trial
- Considerations and guidelines for photic measurement in field studies of the physiological effects of light.Npj biological timing and sleep · 2026Review
- Sleep Health of Athletes of Different Sports: Translation and Validation of the Athlete Sleep Screening Questionnaire to Portuguese.Journal of sleep research · 2026Article
- Blue-Light Filters in Eye Care: A State-of-the-Art Review.Medical sciences (Basel, Switzerland) · 2026Review
- Article
- Light exposure and sleep architecture in real-world settings.Npj biological timing and sleep · 2026Article
- Adaptation across consecutive night shifts at 71°N under Arctic summer daylight and winter darkness: Effects on alertness, sleepiness, and fatigue.Scandinavian journal of work, environment & health · 2026Observational
- The Circadian-Light-Hygiene Hypothesis: A Potential Modulator of Fertility and Birthrate Trends.Biology · 2026Review
150 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Before the invention of electric lighting, humans were primarily exposed to intense (>300 lux) or dim (<30 lux) environmental light-stimuli at extreme ends of the circadian system's dose-response curve to light. Today, humans spend hours per day exposed to intermediate light intensities (30-300 lux), particularly in the evening. Interindividual differences in sensitivity to evening light in this intensity range could therefore represent a source of vulnerability to circadian disruption by modern lighting. We characterized individual-level dose-response curves to light-induced melatonin suppression using a within-subjects protocol. Fifty-five participants (aged 18-30) were exposed to a dim control (<1 lux) and a range of experimental light levels (10-2,000 lux for 5 h) in the evening. Melatonin suppression was determined for each light level, and the effective dose for 50% suppression (ED
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.