ArticleOccupational and environmental medicine2019
Parental occupational exposure to benzene and the risk of childhood and adolescent acute lymphoblastic leukaemia: a population-based study.
Article in Occupational and environmental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The influence of environmental exposures during the preconception period on offspring outcomes: a systematic review.Frontiers in public health · 2025Pooled it
- Paternal exposure to hydrocarbon solvents in the workplace and cancer risk in children and adolescents.Journal of exposure science & environmental epidemiology · 2026Article
- Childhood cancer risk in offspring of mothers occupationally exposed to hydrocarbon solvents.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026Article
- Causes of Childhood Cancer: A Literature Review (2014-2021)-Part 3: Environmental and Occupational Factors.Cancers · 2025Review
- Exposures from Oil and Gas Development and Childhood Leukemia Risk in Colorado: A Population-Based Case-Control Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Multifaceted paternal exposures before conception and their epigenetic impact on offspring.Journal of assisted reproduction and genetics · 2024Review
- Exploring Urban Green Spaces' Effect against Traffic Exposure on Childhood Leukaemia Incidence.International journal of environmental research and public health · 2023Article
- Health Risk Assessment in Children Occupationally and Para-Occupationally Exposed to Benzene Using a Reverse-Translation PBPK Model.International journal of environmental research and public health · 2023Article
- Environmental Risk Factors for Pediatric Acute Leukemia: Methodology and Early Findings.International journal of preventive medicine · 2023Article
- Childhood acute lymphoblastic leukemia survival and spatial analysis of socio-environmental risks in Mexico.Frontiers in oncology · 2023Article
- Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case-Control Study in Pennsylvania, 2009-2017.Environmental health perspectives · 2022Article
- Risk of Cancer in Children of Parents Occupationally Exposed to Hydrocarbon Solvents and Engine Exhaust Fumes: A Register-Based Nested Case-Control Study from Sweden (1960-2015).Environmental health perspectives · 2022Article
- Birth characteristics and childhood leukemia in Switzerland: a register-based case-control study.Cancer causes & control : CCC · 2021Article
- Article
- A Cross-Sectional Study on Benzene Exposure in Pediatric Age and Parental Smoking Habits at Home.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
objectivesOnly a small number of studies have reported on the association of parental occupational exposure to benzene and risk of childhood and adolescent leukaemias. We examined associations with acute lymphoblastic leukaemia (ALL) in this population-based study in Denmark.
methodsBenzene was largely banned from Danish workplaces after 1975, thus this case-control study focused on the immediately prior years. Paediatric cancer cases (<age 20) were ascertained from the Danish Cancer Registry among children born 1968-1974, and controls were selected from population records. Paternal occupation within the 3 months preconception and maternal pregnancy occupation were identified from nationwide pension fund records. Blinded, we assigned benzene exposure using a job-exposure matrix that had been developed for the Danish population. Risk for ALL was estimated using conditional logistic regression. In an exploratory analysis, we also examined other cancers with at least five case parents exposed.
resultsWe identified 217 employed case fathers and 169 employed case mothers, of which 22 (10.1%) and 11 (6.5%), respectively, were exposed to benzene (vs 6.7% and 2.9% of control fathers and mothers). Most exposed parents worked as machine or engine mechanics, or in the shoe industry. Maternal occupational exposure to benzene in pregnancy was related to increased risk of ALL in offspring (adjusted OR=2.28, 95% CI 1.17 to 4.41), while paternal preconceptional benzene exposure was not as strongly associated (adjusted OR=1.40, 95% CI 0.88 to 2.22).
conclusionsOur study supports an increased risk for ALL with parental occupational benzene exposure.
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