Evidence map›Paper›PMID 31138660›Full record

ArticleeNeuro

Pubertal Testosterone Programs Adult Behavioral Adaptations to Sexual Experience through Infralimbic Cortex ΔFosB.

Kayla C De Lorme, Nancy A Staffend-Michael, Sarah C Simmons, Alfred J Robison, Cheryl L Sisk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kayla C De LormeDepartment of Psychology, Michigan State University, East Lansing, MI 48824 kdelorme@gustavus.edu.
Nancy A Staffend-MichaelNeuroscience Program, Michigan State University, East Lansing, MI 48824.
Sarah C SimmonsNeuroscience Program, Michigan State University, East Lansing, MI 48824.
Alfred J RobisonNeuroscience Program, Michigan State University, East Lansing, MI 48824.
Cheryl L SiskDepartment of Psychology, Michigan State University, East Lansing, MI 48824.ORCID 0000-0002-4642-607X
Michigan State University · USGustavus Adolphus College · US

Funding

Small molecule modulators of ΔFosB FunctionR01DA040621 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI NESTLER, ERIC J., ROBISON, ALFRED J · 2016 to 2025
$7.1M
Translational Studies of ADAMTS7 a Novel GWAS Locus for Coronary AtherosclerosisR01HL111694 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI REILLY, MUREDACH P · 2012 to 2015
$2.4M
Pubertal Organization of Brain and BehaviorR01MH068764 · NIMH · MICHIGAN STATE UNIVERSITY · PI SISK, CHERYL L. · 2004 to 2012
$2.4M
Mechanisms of genomic reprogramming and transcriptional activation in the embryoR01GM111694 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HARRISON, MELISSA · 2015 to 2019
$1.6M
Determination of morphological and molecular adaptations in ventral tegmental area dopamine neurons by chronic morphineF31DA042502 · NIDA · MICHIGAN STATE UNIVERSITY · PI SIMMONS, SARAH EMILY COOPER · 2017 to 2018
$64k
NHLBI NIH HHS R01 HL111694NIDA NIH HHS F31 DA042502NIDA NIH HHS R01 DA040621NIGMS NIH HHS R01 GM111694NIMH NIH HHS R01 MH068764
6 · The paper itself

Abstract

Acquisition of social proficiency entails behavioral adaptations to social experience, including both behavioral flexibility and inhibition of behaviors inappropriate in specific social contexts. Here, we investigated the contributions of testosterone and ΔFosB, a transcription factor linked to experience-dependent neural plasticity, to the adolescent maturation of social proficiency in male-female social interactions. To determine whether pubertal testosterone organizes circuits underlying social proficiency, we first compared behavioral adaptations to sexual experience in male Syrian hamsters that were deprived of testosterone during puberty (prepubertal castration; NoT@P) to those of males deprived of testosterone for an equivalent period of time in adulthood (postpubertal castration; T@P). All males were given testosterone replacement in adulthood for two weeks before sexual behavior testing, where males were allowed to interact with a receptive female once per week for five consecutive weeks. T@P males showed the expected decrease in ectopic (mis-directed) mounts with sexual experience, whereas NoT@P males did not. In addition, sexual experience induced

Indexed as

Adaptation, PhysiologicalAnimalsFemaleInterpersonal RelationsMaleMesocricetusPrefrontal CortexProto-Oncogene Proteins c-fosPubertySexual Behavior, AnimalTestosteroneProto-Oncogene Proteins c-fosTestosteroneectopic mountsmedial prefrontal cortexpubertysocial proficiencytestosteroneΔFosB

Identifiers

PMID31138660
PMCPMC6553569
OpenAlexW2947048562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.