Evidence map›Paper›PMID 31138657›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Growth Factor Signaling Regulates Mechanical Nociception in Flies and Vertebrates.

Roger Lopez-Bellido, Stephanie Puig, Patrick J Huang, Chang-Ru Tsai, Heather N Turner, Michael J Galko, Howard B Gutstein

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. eLife · 2025
    Article
  7. Mechanical Nociception Assay inCold Spring Harbor protocols · 2025
    Article
  8. The Nociceptor Primary Cilium Contributes to Mechanical Nociceptive Threshold and Inflammatory and Neuropathic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Nociception in fruit fly larvae.Frontiers in pain research (Lausanne, Switzerland) · 2023
    Review
  16. eLife · 2022
    Article
  17. Dynamic and static biomechanical traits of cardiac fibrosis.Frontiers in bioengineering and biotechnology · 2022
    Review
  18. Review
  19. Pain in sickle cell disease: current and potential translational therapies.Translational research : the journal of laboratory and clinical medicine · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Roger Lopez-BellidoDepartment of Anesthesiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.ORCID 0000-0002-4610-8522
Stephanie PuigDepartment of Anesthesiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.ORCID 0000-0001-7200-1094
Patrick J HuangDepartment of Genetics, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030.
Chang-Ru TsaiProgram in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030.
Heather N TurnerNeuroscience Graduate Program, Graduate School of Biomedical Sciences, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, and.ORCID 0000-0002-5819-5600
Michael J GalkoDepartment of Genetics, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, mjgalko@mdanderson.org gutsteinhb@upmc.edu.ORCID 0000-0002-3759-2017
Howard B GutsteinDepartment of Anesthesiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, mjgalko@mdanderson.org gutsteinhb@upmc.edu.ORCID 0000-0001-6808-3429
The University of Texas MD Anderson Cancer Center · USUniversity of Pittsburgh · USBaylor College of Medicine · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
The molecular and genetic bases of diverse tissue repair responses in postembryonic DrosophilaR35GM126929 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GALKO, MICHAEL J · 2018 to 2025
$3.4M
The role of RTK signaling in opioid toleranceR01DA036680 · NIDA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GUTSTEIN, HOWARD B · 2014 to 2018
$1.8M
Development of a mechanical nociceptive sensitization model in DrosophilaR21NS087360 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GALKO, MICHAEL J · 2014 to 2015
$440k
Upgrading an existing NIKON A1-confocal with LUNV Laser Launch and DU-G detectorS10OD024976 · OD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LOZANO, GUILLERMINA · 2018 to 2018
$202k
Dissecting the Molecular Mechanisms of Cold Nociception in Drosophila LarvaeF31NS083306 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI TURNER, HEATHER NICOLE · 2013 to 2014
$38k
NCI NIH HHS P30 CA016672NIDA NIH HHS R01 DA036680NIGMS NIH HHS R35 GM126929NIH HHS S10 OD024976NINDS NIH HHS F31 NS083306NINDS NIH HHS R21 NS087360
6 · The paper itself

Abstract

Mechanical sensitization is one of the most difficult clinical pain problems to treat. However, the molecular and genetic bases of mechanical nociception are unclear. Here we develop a

Indexed as

AnimalsAnimals, Genetically ModifiedDrosophila melanogasterIntercellular Signaling Peptides and ProteinsLarvaMaleNociceptionPhysical StimulationRatsRats, Sprague-DawleySensory Receptor CellsSignal TransductionSpecies SpecificityVascular Endothelial Growth Factor Receptor-2VertebratesIntercellular Signaling Peptides and ProteinsKdr protein, ratVascular Endothelial Growth Factor Receptor-2Drosophilaopioid tolerancepainPDGF/PDGFRTRP ion channelsVEGF/VEGFR

Identifiers

PMID31138657
PMCPMC6650988
OpenAlexW2947023989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.