Evidence map›Paper›PMID 31138629›Full record

ArticleJournal of bacteriology2019

Single-Cell Microscopy Reveals That Levels of Cyclic di-GMP Vary among Bacillus subtilis Subpopulations.

Cordelia A Weiss, Jakob A Hoberg, Kuanqing Liu, Benjamin P Tu, Wade C Winkler

Abstract read
In one paragraph

Article in Journal of bacteriology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. c-di-GMP-Dependent Regulation of Motility bybioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Frontiers in microbiology · 2022
    Article
  13. Article
  14. Molecular genetics of surfactin and its effects on different sub-populations ofBiotechnology reports (Amsterdam, Netherlands) · 2021
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Frontiers in microbiology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cordelia A WeissDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
Jakob A HobergDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
Kuanqing LiuDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Benjamin P TuDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Wade C WinklerDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA wwinkler@umd.edu.

Funding

Metabolic signals regulating cell growth versus survivalR35GM136370 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Benjamin P Tu · 2020 to 2026
$2.8M
Post-initiation regulatory mechanisms controlling ethanolamine utilizationR01AI110432 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GARSIN, DANIELLE A, WINKLER, WADE · 2015 to 2019
$2.2M
Training in Host-pathogens interactionsT32AI089621 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI LEE, VINCENT T, MCIVER, KEVIN S. · 2010 to 2025
$2.1M
Training Program in Cell & Molecular BiologyT32GM080201 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI DELWICHE, CHARLES F · 2009 to 2019
$1.6M
Post-initiation regulatory mechanisms controlling ethanolamine utilizationR56AI110432 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GARSIN, DANIELLE A, WINKLER, WADE · 2014 to 2014
$431k
NIAID NIH HHS R01 AI110432NIAID NIH HHS R56 AI110432NIAID NIH HHS T32 AI089621NIGMS NIH HHS R35 GM136370NIGMS NIH HHS T32 GM080201
6 · The paper itself

Abstract

The synthesis of signaling molecules is one strategy bacteria employ to sense alterations in their environment and rapidly adjust to those changes. In Gram-negative bacteria, bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) regulates the transition from a unicellular motile state to a multicellular sessile state. However, c-di-GMP signaling has been less intensively studied in Gram-positive organisms. To that end, we constructed a fluorescent

Indexed as

Bacillus subtilisBacterial ProteinsCyclic GMPGenes, ReporterLuminescent ProteinsMicroscopySingle-Cell AnalysisBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPLuminescent Proteinsyellow fluorescent protein, BacteriaBacillus subtilisbiofilmcyclic di-GMPmicroscopyriboswitch

Identifiers

PMID31138629
PMCPMC6657594

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.