Evidence map›Paper›PMID 31138612›Full record

ArticleInfection and immunity2019

Deletion of a 19-Amino-Acid Region in Clostridioides difficile TcdB2 Results in Spontaneous Autoprocessing and Reduced Cell Binding and Provides a Nontoxic Immunogen for Vaccination.

Sarah J Bland, Jason L Larabee, Tyler M Shadid, Mark L Lang, Jimmy D Ballard

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. HumanbioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sarah J BlandDepartment of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Jason L LarabeeDepartment of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Tyler M ShadidDepartment of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Mark L LangDepartment of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Jimmy D BallardDepartment of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA jimmy-ballard@ouhsc.edu.ORCID 0000-0001-8824-9609
University of Oklahoma Health Sciences Center · US

Funding

Molecular Basis of Immunity - Kirschtein-NRSAT32AI007633 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CUNNINGHAM, MADELEINE W. · 2001 to 2022
$4.0M
Differential Effects of TcdB1 and TcdB2 in C. difficile diseaseR01AI119048 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI BALLARD, JIMMY D. · 2015 to 2024
$3.8M
NIAID NIH HHS R01 AI119048NIAID NIH HHS T32 AI007633
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBacterial ProteinsBacterial VaccinesCHO CellsClostridioides difficileCricetulusGlycosylationHeLa CellsHumansMiceProtein ConformationProtein DomainsRepressor ProteinsSequence DeletionVaccinationBacterial ProteinsBacterial VaccinesRepressor ProteinsTcdC protein, Clostridium difficileautoprocessingClostridioides difficileClostridium difficileimmunizationTcdBtoxin B

Identifiers

PMID31138612
PMCPMC6652773
OpenAlexW2944954453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.