Evidence map›Paper›PMID 31138601›Full record

ArticleMolecular cancer research : MCR2019

Serine/Arginine-Rich Splicing Factor 3 Modulates the Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2.

James T DeLigio, Shaun C Stevens, Gina S Nazario-Muñoz, H Patrick MacKnight, Keli K Doe, Charles E Chalfant, Margaret A Park

Open access · greenAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. SRSF3 determines TScience advances · 2026
    Article
  2. Targeting RNA splicing modulation: new perspectives for anticancer strategy?Journal of experimental & clinical cancer research : CR · 2025
    Review
  3. Mechanisms of RNA alternative splicing dysregulation in triple-negative breast cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Review
  4. Oncogenic SRSF3 in health and diseases.International journal of biological sciences · 2023
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

James T DeLigio *Department of Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), Richmond Virginia.
Shaun C Stevens *Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida.
Gina S Nazario-MuñozDepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, Florida.ORCID 0000-0002-5522-7662
H Patrick MacKnightDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), Richmond Virginia.
Keli K DoeDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), Richmond Virginia.
Charles E ChalfantDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), Richmond Virginia. mapark@usf.edu cechalfant@usf.edu.
Margaret A ParkDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), Richmond Virginia. mapark@usf.edu cechalfant@usf.edu.
Virginia Commonwealth University · USJohnson & Johnson (United States) · USUniversity of South Florida · US

Funding

The roles of ceramide and its derivatives in A. phagocytophilum pathogenesisR01AI139072 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHARLES E. CHALFANT, Jason A Carlyon · 2018 to 2026
$5.7M
The utilization of photonics technology to rapidly detect bioactive lipids associated with preeclampsia developmentU01HD087198 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHALFANT, CHARLES E., WALSH, SCOTT W · 2015 to 2015
$4.2M
The functional role of the cPLA2alpha/C1P interaction in sepsis resolutionR01HL125353 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI BROWN, RHODERICK E, CHALFANT, CHARLES E. · 2014 to 2018
$4.0M
Center for Clinical and Translational ResearchKL2TR000057 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2014
$1.4M
Regulation of caspase 9 RNA splicing in NSCLC cancerR01CA154314 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHALFANT, CHARLES E. · 2011 to 2014
$1.2M
Sphingolipid Regulation of Caspase 9 Alternative SplicingR01CA117950 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHALFANT, CHARLES E. · 2006 to 2009
$919k
The Role of hnRNP L in Non-Small Cell Lung CancerR21CA201195 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI PARK, MARGARET AMY · 2016 to 2016
$166k
The role of RNA splicing in non-small cell lung cancerI01BX001792 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI CHALFANT, CHARLES E. · 2013 to 2024
–
BLRD Research Career Scientist Award ApplicationIK6BX004603 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI CHALFANT, CHARLES E. · 2019 to 2025
–
BLRD VA I01 BX001792BLRD VA IK6 BX004603NCATS NIH HHS KL2 TR000057NCI NIH HHS R01 CA117950NCI NIH HHS R01 CA154314NCI NIH HHS R21 CA201195NHLBI NIH HHS R01 HL125353NIAID NIH HHS R01 AI139072NICHD NIH HHS U01 HD087198
6 · The paper itself

Abstract

Triple negative breast cancer (TNBC) has an unusually low 5-year survival rate linked to higher metastatic rates. Our laboratory recently delineated a role for the alternative RNA splicing (AS) of cytoplasmic polyadenylation element binding protein 2 (CPEB2), via inclusion/exclusion of exon 4, in the metastasis of TNBC. In these studies, the mechanism governing the inclusion/exclusion of exon 4 was examined. Specifically, the RNA

Indexed as

Alternative SplicingAnoikisBinding SitesCell Line, TumorConsensus SequenceExonsFemaleGene Expression Regulation, NeoplasticHumansMutationNeoplasm MetastasisProtein BindingRNA-Binding ProteinsSerine-Arginine Splicing FactorsTriple Negative Breast NeoplasmsUp-RegulationCPEB2 protein, humanRNA-Binding ProteinsSerine-Arginine Splicing FactorsSRSF3 protein, human

Identifiers

PMID31138601
PMCPMC6726571
OpenAlexW2947619722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.