ArticleBMJ case reports2019
Acute retinal necrosis in a patient with remote severe herpes simplex encephalitis.
Article in BMJ case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Outcomes of Patients with Acute Retinal Necrosis (ARN) presenting to a Canadian tertiary care centre: a 5-year retrospective cohort study.Journal of ophthalmic inflammation and infection · 2026Article
- A Comprehensive Update on Retinal Vasculitis: Etiologies, Manifestations and Treatments.Journal of clinical medicine · 2022Review
- Acute retinal necrosis caused by co-infection with multiple viruses in a natalizumab-treated patient: a case report and brief review of literature.BMC ophthalmology · 2021Review
- Neuro-ophthalmological consequences of acute influenza A encephalitis in a genetically predisposed child.BMJ case reports · 2020Article
- Ocular manifestations of herpes simplex virus.Current opinion in ophthalmology · 2019Review
- Dementia and cognitive impairment in adults as sequels of HSV-1-related encephalitis: a review.Dementia & neuropsychologiaReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 60-year-old man with a history of severe herpes simplex virus type 1 (HSV-1) encephalitis 2 years prior presented with acute onset of visual loss in the left eye. Dilated funduscopic examination showed retinitis and occlusive vasculitis with retinal necrosis. PCR of the vitreous fluid was positive for HSV-1, and he was diagnosed with acute retinal necrosis (ARN) due to HSV-1. The patient was treated with intravenous acyclovir and intravitreous foscarnet for 2 weeks, followed by high dose oral valacyclovir for 2 weeks. He was subsequently placed on planned life-long suppressive valacyclovir. His case demonstrates that acute visual loss concomitant with or subsequent to HSV-1 encephalitis warrants suspicion of ARN. Prompt therapy with effective antiviral medication is necessary to reduce the risk of sight-threatening complications. Chronic suppression with oral antiviral therapy after ARN is recommended to prevent involvement of the contralateral eye, though there is no consensus on the duration and dosage of antivirals.
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Registered trials
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