Evidence map›Paper›PMID 31138580›Full record

Observational studyBMJ open2019

What is the prevalence, and what are the clinical correlates, of insulin resistance in young people presenting for mental health care? A cross-sectional study.

Elizabeth M Scott, Joanne S Carpenter, Frank Iorfino, Shane P M Cross, Daniel F Hermens, Jeanne Gehue, Chloe Wilson, Django White, Sharon L Naismith, Adam J Guastella and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elizabeth M ScottBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Joanne S CarpenterBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-9766-6700
Frank IorfinoBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-1109-0972
Shane P M CrossBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Daniel F HermensBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Jeanne GehueBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Chloe WilsonBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Django WhiteBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Sharon L NaismithBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Adam J GuastellaBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Ian B HickieBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo report the distribution and predictors of insulin resistance (IR) in young people presenting to primary care-based mental health services.

designCross-sectional.

settingHeadspace-linked clinics operated by the Brain and Mind Centre of the University of Sydney.

participants768 young people (66% female, mean age 19.7±3.5, range 12-30 years).

main outcome measuresIR was estimated using the updated homeostatic model assessment (HOMA2-IR). Height and weight were collected from direct measurement or self-report for body mass index (BMI).

resultsFor BMI, 20.6% of the cohort were overweight and 10.2% were obese. However, <1% had an abnormally high fasting blood glucose (>6.9 mmol/L). By contrast, 9.9% had a HOMA2-IR score >2.0 (suggesting development of IR) and 11.7% (n=90) had a score between 1.5 and 2. Further, there was a positive correlation between BMI and HOMA2-IR (r=0.44, p<0.001). Participants in the upper third of HOMA2-IR scores are characterised by younger age, higher BMIs and depression as a primary diagnosis. HOMA2-IR was predicted by younger age (β=0.19, p<0.001) and higher BMI (β=0.49, p<0.001), together explaining 22% of the variance (F

conclusionsEmerging IR is evident in a significant subgroup of young people presenting to primary care-based mental health services. While the major modifiable risk factor is BMI, a large proportion of the variance is not accounted for by other demographic, clinical or treatment factors. Given the early emergence of IR, secondary prevention interventions may need to commence prior to the development of full-threshold or major mood or psychotic disorders.

Indexed as

Insulin ResistanceAdolescentAdultAustraliaBlood GlucoseBody Mass IndexChildCohort StudiesCross-Sectional StudiesFastingFemaleHumansLinear ModelsMaleMental DisordersObesityBlood Glucosedepressionearly interventionglucoseinsulin resistancemental health

Identifiers

PMID31138580
PMCPMC6550004

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.