Evidence map›Paper›PMID 31138566›Full record

ArticleAntimicrobial agents and chemotherapy2019

Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice.

Roger V Ortines, Yu Wang, Haiyun Liu, Dustin A Dikeman, Bret L Pinsker, Robert J Miller, Sophia E Kim, Nicole E Ackerman, Joe F Rizkallah, LeeAnn T Marcello and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. In vivo mRNA expression of a multi-mechanistic mAb combination protects against Staphylococcus aureus infection.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  2. Review
  3. Article
  4. Article
  5. Mucosa-Associated Invariant T Cell Hypersensitivity toJournal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Roger V Ortines *Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yu Wang *Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Haiyun LiuDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Dustin A DikemanDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Bret L PinskerDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Robert J MillerDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sophia E KimDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nicole E AckermanDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Joe F RizkallahDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
LeeAnn T MarcelloDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Taylor S CohenDepartment of Microbial Sciences, AstraZeneca, Gaithersburg, Maryland, USA.
Christine TkaczykDepartment of Microbial Sciences, AstraZeneca, Gaithersburg, Maryland, USA.
Bret R SellmanDepartment of Microbial Sciences, AstraZeneca, Gaithersburg, Maryland, USA.
Lloyd S MillerDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA lloydmiller@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · USAstraZeneca (United States) · US

Funding

IL-36 responses in Staphylococcus aureus driven skin inflammationR01AR073665 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2018 to 2022
$1.8M
STAT3-mediated immunity to Staphylococcus aureus in skinR01AR069502 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2016 to 2020
$1.8M
NIAMS NIH HHS R01 AR069502NIAMS NIH HHS R01 AR073665
6 · The paper itself

Abstract

Surgical site infections (SSIs) are commonly caused by

Indexed as

AnimalsAnti-Bacterial AgentsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBacterial ProteinsBroadly Neutralizing AntibodiesCoagulaseLeukocidinsMethicillin-Resistant Staphylococcus aureusMice, Inbred C57BLMice, Inbred StrainsStaphylococcal InfectionsSurgical Wound InfectionVancomycinAnti-Bacterial AgentsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBacterial ProteinsBroadly Neutralizing AntibodiesClfA protein, Staphylococcus aureusCoagulaseLeukocidinsleukocidin S-component protein, StaphylococcusLukF protein, Staphylococcus aureussuvratoxumabVancomycinalpha-toxinClfAclumping factor AhlaleukocidinMRSAStaphylococcus aureussurgical

Identifiers

PMID31138566
PMCPMC6658795
OpenAlexW2946307971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.