Evidence map›Paper›PMID 31138536›Full record

ArticleDisease models & mechanisms2019

Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated

Stephanie LaHaye, Uddalak Majumdar, Jun Yasuhara, Sara N Koenig, Adrianna Matos-Nieves, Rahul Kumar, Vidu Garg

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Genetics of Congenital Heart Disease.Clinics in perinatology · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Bicuspid Aortic Valve-Associated Regulatory Regions RevealArteriosclerosis, thrombosis, and vascular biology · 2023
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. In Vivo and In Vitro Genetic Models of Congenital Heart Disease.Cold Spring Harbor perspectives in biology · 2021
    Review
  11. Mending a broken heart:Disease models & mechanisms · 2021
    Review
  12. Article
  13. Extracellular Matrix Disparities in anFrontiers in cardiovascular medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Stephanie LaHayeCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Uddalak MajumdarCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Jun YasuharaCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Sara N KoenigCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Adrianna Matos-NievesCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Rahul KumarCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Vidu GargCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH 43205, USA vidu.garg@nationwidechildrens.org.ORCID 0000-0002-3778-5927
Nationwide Children's Hospital · US

Funding

Training To Provide the Knowledge, Skills, and Culture To the Next Generation of Cardiovascular ScientistsT32HL134616 · NHLBI · OHIO STATE UNIVERSITY · PI Brandon J Biesiadecki, Jill A Rafael-Fortney · 2017 to 2026
$2.6M
Genetic Regulation of Cardiac SeptationR01HL088965 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GARG, VIDU · 2007 to 2011
$1.9M
Molecular Mechanisms of Aortic Valve FormationR01HL121797 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GARG, VIDU · 2015 to 2018
$1.6M
NHLBI NIH HHS R01 HL088965NHLBI NIH HHS R01 HL121797NHLBI NIH HHS T32 HL134616
6 · The paper itself

Abstract

Congenital heart defects affect ∼2% of live births and often involve malformations of the semilunar (aortic and pulmonic) valves. We previously reported a highly penetrant

Indexed as

AnimalsAnimals, NewbornAortic ValveAortic Valve StenosisEmbryo, MammalianEpithelial-Mesenchymal TransitionGATA4 Transcription FactorGene Expression Regulation, DevelopmentalHeart Defects, CongenitalHeterozygoteMice, Inbred C57BLMutationWnt Signaling PathwayGata4 protein, mouseGATA4 Transcription FactorAortic valve stenosisCongenital heart diseaseGATA4GeneticsValve development

Identifiers

PMID31138536
PMCPMC6602309
OpenAlexW2947453525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.