ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2019
The Effect of Upper Airway Surgery on Loop Gain in Obstructive Sleep Apnea.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02696629 (The Impact of Sleep Apnea Treatment on Physiology Traits in Chinese Patients With Obstructive Sleep Apnea), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Sleep Apnea Treatment on Physiology Traits in Chinese Patients With Obstructive Sleep Apnea
Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- A randomized controlled trial of oxygen therapy for patients who do not respond to upper airway surgery for obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Trial
- Article
- Endophenotypes of OSA that are responsive to pharmacological agents: a narrative review of trazodone and atomoxetine.Sleep & breathing = Schlaf & Atmung · 2026Review
- Is Obstructive Sleep Apnea in People Without Obesity a Unique Disease?Archivos de bronconeumologia · 2025Article
- Polysomnographic endotypes of successful multilevel upper airway surgery for obstructive sleep apnea.Sleep · 2025Article
- Obstructive Sleep Apnea Endophenotypes.Sleep science (Sao Paulo, Brazil) · 2025Review
- Upper Airway Collapsibility During Rapid Eye Movement Sleep Is Associated With the Response to Upper Airway Surgery for Obstructive Sleep Apnea.Clinical and experimental otorhinolaryngology · 2025Article
- Acetazolamide as an Add-on Therapy Following Barbed Reposition Pharyngoplasty in Obstructive Sleep Apnea: A Randomized Controlled Trial.Life (Basel, Switzerland) · 2024Article
- Obstructive Sleep Apnea: Pathophysiology and Endotypes.ATS scholar · 2023Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- Summary of drug therapy to treat cognitive impairment-induced obstructive sleep apnea.Frontiers in cellular neuroscience · 2023Review
- Enhanced expiratory rebreathing space for high loop gain sleep apnea treatment.Frontiers in sleep · 2023Review
- Examining the impact of multilevel upper airway surgery on the obstructive sleep apnoea endotypes and their utility in predicting surgical outcomes.Respirology (Carlton, Vic.) · 2022Article
- Implications of Obstructive Sleep-related Breathing Disorder in Dentistry: Focus on Snoring and Obstructive Sleep Apnea.Dental research and oral health · 2022Article
- Alternative Therapies for Obstructive Sleep Apnea.American journal of respiratory and critical care medicine · 2021Article
- OSA Upper Airways Surgery: A Targeted Approach.Medicina (Kaunas, Lithuania) · 2021Review
- A scalable method of determining physiological endotypes of sleep apnea from a polysomnographic sleep study.Sleep · 2021Article
- The role of reactive oxygen species in cognitive impairment associated with sleep apnea.Experimental and therapeutic medicine · 2020Article
- Endotypes and phenotypes in obstructive sleep apnea.Current opinion in pulmonary medicine · 2020Review
- Contemporary Concise Review 2019: Sleep and ventilation.Respirology (Carlton, Vic.) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
STUDY
objectivesControversy exists as to whether elevated loop gain is a cause or consequence of obstructive sleep apnea (OSA). Upper airway surgery is commonly performed in Asian patients with OSA who have failed positive airway pressure therapy and who are thought to have anatomical predisposition to OSA. We hypothesized that high loop gain would decrease following surgical treatment of OSA due to reduced sleep apnea severity.
methodsPolysomnography was performed preoperatively and postoperatively to assess OSA severity in 30 Chinese participants who underwent upper airway surgery. Loop gain was calculated using a validated clinically-applicable method by fitting a feedback control model to airflow.
resultsPatients were followed up for a median (interquartile range) of 130 (62, 224) days after surgery. Apnea-hypopnea index (AHI) changed from 60.8 (33.7, 71.7) to 18.4 (9.9, 42.5) events/h (
conclusionsHigh loop gain was reduced by surgical treatment of OSA in our cohort. These data suggest that elevated loop gain may be acquired in OSA and may provide mechanistic insight into improvement in OSA with upper airway surgery. CLINICAL
trial registrationRegistry: ClinicalTrials.gov, Title: The Impact of Sleep Apnea Treatment on Physiology Traits in Chinese Patients With Obstructive Sleep Apnea, Identifier: NCT02696629, URL: https://clinicaltrials.gov/show/NCT02696629.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.