ArticleMicrobial cell factories2019
A newly isolated human intestinal bacterium strain capable of deglycosylating flavone C-glycosides and its functional properties.
Article in Microbial cell factories, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
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- Anti-Proliferative Potential of Cynaroside and Orientin-In Silico (DYRK2) and In Vitro (U87 and Caco-2) Studies.International journal of molecular sciences · 2023Article
- Enzymatic β-elimination in natural product O- and C-glycoside deglycosylation.Nature communications · 2023Article
- Theoretical study on the glycosidic C-C bond cleavage of 3''-oxo-puerarin.Scientific reports · 2023Article
- Evaluation of Antioxidant Activity and Biotransformation ofMolecules (Basel, Switzerland) · 2022Article
- A newly isolated human intestinal strain deglycosylating flavonoid C-glycosides.Archives of microbiology · 2022Article
- New Insights into the Efficacy of Aspalathin and Other Related Phytochemicals in Type 2 Diabetes-A Review.International journal of molecular sciences · 2021Review
- Enterococcus faecium PNC01 isolated from the intestinal mucosa of chicken as an alternative for antibiotics to reduce feed conversion rate in broiler chickens.Microbial cell factories · 2021Article
- Article
- Deglycosylation of the IsoflavoneApplied and environmental microbiology · 2020Article
- Regulation of GABAFrontiers in pharmacology · 2020Article
- Gut Microbiota Status in COVID-19: An Unrecognized Player?Frontiers in cellular and infection microbiology · 2020Review
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Authors and funding
6 authors.
Funding
Abstract
backgroundFlavone C-glycosides are difficult to be deglycosylated using traditional chemical methods due to their solid carbon-carbon bond between sugar moieties and aglycones; however, some bacteria may easily cleave this bond because they generate various specific enzymes.
resultsA bacterial strain, named W12-1, capable of deglycosylating orientin, vitexin, and isovitexin to their aglycones, was isolated from human intestinal bacteria in this study and identified as Enterococcus faecalis based on morphological examination, physiological and biochemical identification, and 16S rDNA sequencing. The strain was shown to preferentially deglycosylate the flavone C-glycosides on condition that the culture medium was short of carbon nutrition sources such as glucose and starch, and its deglycosylation efficiency was negatively correlated with the content of the latter two substances.
conclusionThis study provided a new bacterial resource for the cleavage of C-glycosidic bond of flavone C-glycosides and reported the carbon nutrition sources reduction induced deglycosylation for the first time.
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