Trial reportCritical care (London, England)2019
Albumin infusion rate and plasma volume expansion: a randomized clinical trial in postoperative patients after major surgery.
Trial report in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Agreement Between Methods Assessing Changes in Plasma Volume During Fluid Therapy-A Post Hoc Analysis of a Randomized Trial.Acta anaesthesiologica Scandinavica · 2026Trial
- Blood volume and hemodynamics during treatment of major hemorrhage with Ringer solution, 5% albumin, and 20% albumin: a single-center randomized controlled trial.Critical care (London, England) · 2024Trial
- Effects of different mean arterial pressure targets on plasma volume, ANP and glycocalyx-A randomized trial.Acta anaesthesiologica Scandinavica · 2021Trial
- Article
- Albumin kinetics, intravascular fluid volume, and respiratory function in pigs ventilated at different levels of mechanical power following crystalloid vs. albumin infusion.Intensive care medicine experimental · 2026Article
- Effects ofResuscitation plus · 2026Review
- A retrospective study on the use of albumin in the management of complications of decompensated cirrhosis from a major teaching hospital in Canada.Canadian liver journal · 2025Article
- Where does the fluid go?Annals of intensive care · 2025Review
- Estimating the plasma volume by infusing albumin: a retrospective feasibility study.Intensive care medicine experimental · 2025Article
- Transcriptomic analysis of iPSC-derived endothelium reveals adaptations to high altitude hypoxia in energy metabolism and inflammation.PLoS genetics · 2025Article
- Perioperative fluid therapy in adults and children: a narrative review.Frontiers in medicine · 2025Review
- Intraoperative Colloid Use on Post-operative Renal Function.Current anesthesiology reports · 2024Article
- The Association of Pre-operative Serum Albumin Levels and Post-operative In-Hospital Death in Patients Undergoing Gastrointestinal Surgeries in Thailand: A Retrospective Cohort Study.Drugs - real world outcomes · 2023Article
- Blood volume in patients likely to be preload responsive: a post hoc analysis of a randomized controlled trial.Intensive care medicine experimental · 2023Article
- The glycocalyx as a permeability barrier: basic science and clinical evidence.Critical care (London, England) · 2022Review
- Enteral nutrition and acute mesenteric ischemia.Intensive care medicine · 2022Article
- Plasma disappearance rate of albumin when infused as a 20% solution.Critical care (London, England) · 2022Review
- Albumin Infusion May Improve the Prognosis of Critical COVID-19 Patients with Hypoalbuminemia in the Intensive Care Unit: A Retrospective Cohort Study.Infection and drug resistance · 2022Article
- Rapid 500 mL albumin bolus versus rapid 200 mL bolus followed by slower continuous infusion in post-cardiac surgery patients: a pilot before-and-after study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2021Article
- Interstitial washdown and vascular albumin refill during fluid infusion: novel kinetic analysis from three clinical trials.Intensive care medicine experimental · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundOptimal infusion rate of colloids in patients with suspected hypovolemia is unknown, and the primary objective of the present study was to test if plasma volume expansion by 5% albumin is greater if fluid is administered slowly rather than rapidly.
methodsPatients with signs of hypoperfusion after major abdominal surgery were randomized to intravenous infusion of 5% albumin at a dose of 10 ml/kg (ideal body weight) either rapidly (30 min) or slowly (180 min). Plasma volume was measured using radiolabeled albumin at baseline, at 30 min, and at 180 min after the start of infusion. Primary outcome was change in plasma volume from the start of infusion to 180 min after the start of infusion. Secondary outcomes included the change in the area under the plasma volume curve and transcapillary escape rate (TER) for albumin from 180 to 240 min after the start of albumin infusion.
resultsA total of 33 and 31 patients were included in the analysis in the slow and rapid groups, respectively. The change in plasma volume from the start of infusion to 180 min did not differ between the slow and rapid infusion groups (7.4 ± 2.6 vs. 6.5 ± 4.1 ml/kg; absolute difference, 0.9 ml/kg [95%CI, - 0.8 to 2.6], P = 0.301). Change in the area under the plasma volume curve was smaller in the slow than in the rapid infusion group and was 866 ± 341 and 1226 ± 419 min ml/kg, respectively, P < 0.001. TER for albumin did not differ and was 5.3 ± 3.1%/h and 5.4 ± 3%/h in the slow and in the rapid infusion groups, respectively, P = 0.931.
conclusionsThis study does not support our hypothesis that a slow infusion of colloid results in a greater plasma volume expansion than a rapid infusion. Instead, our result of a smaller change in the area under the plasma volume curve indicates that a slow infusion results in a less efficient plasma volume expansion, but further studies are required to confirm this finding. A rapid infusion has no effect on vascular leak as measured after completion of the infusion.
trial registrationEudraCT2013-004446-42 registered December 23, 2014.
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