ArticleMicrobial cell factories2019
Key sub-community dynamics of medium-chain carboxylate production.
Article in Microbial cell factories, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- A double-staining automated flow cytometry method for real-time monitoring of bacteria in continuous bioreactors.NPJ systems biology and applications · 2026Article
- Steering the Chain-Elongating Microbiome to C8 or C6 Production with Ethanol and Lactate as Coelectron Donors.Environmental science & technology · 2025Article
- Towards net zero land biotechnology: an assessment of biogenic feedstock potential for selected bioprocesses in Germany.Biotechnology for biofuels and bioproducts · 2025Article
- Medium-chain carboxylates production from plant waste: kinetic study and effect of an enriched microbiome.Biotechnology for biofuels and bioproducts · 2024Article
- Article
- Mixotrophic chain elongation with syngas and lactate as electron donors.Microbial biotechnology · 2023Article
- Why do lactic acid bacteria thrive in chain elongation microbiomes?Frontiers in bioengineering and biotechnology · 2023Article
- Machine learning-assisted identification of bioindicators predicts medium-chain carboxylate production performance of an anaerobic mixed culture.Microbiome · 2022Article
- Recovery Techniques Enabling Circular Chemistry from Wastewater.Molecules (Basel, Switzerland) · 2022Review
- Predicting the Presence and Abundance of Bacterial Taxa in Environmental Communities through Flow Cytometric Fingerprinting.mSystems · 2021Article
- Microbial Ecological Mechanism for Long-Term Production of High Concentrations ofApplied and environmental microbiology · 2021Article
- Effect of Oxygen Contamination on Propionate and Caproate Formation in Anaerobic Fermentation.Frontiers in bioengineering and biotechnology · 2021Article
- A Downstream Processing Cascade for Separation of Caproic and Caprylic Acid from Maize Silage-Based Fermentation Broth.Frontiers in bioengineering and biotechnology · 2021Article
- Long-Term Continuous Extraction of Medium-Chain Carboxylates by Pertraction With Submerged Hollow-Fiber Membranes.Frontiers in bioengineering and biotechnology · 2021Article
- Diverse Profile of Fermentation Byproducts From Thin Stillage.Frontiers in bioengineering and biotechnology · 2021Article
- Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical Atherosclerosis.Frontiers in immunology · 2021Article
- Hydrogen as a Co-electron Donor for Chain Elongation With Complex Communities.Frontiers in bioengineering and biotechnology · 2021Article
- Mixed Acid Fermentation of Carbohydrate-Rich Dairy Manure Hydrolysate.Frontiers in bioengineering and biotechnology · 2021Article
- Three NovelMicroorganisms · 2020Article
- Draft Genome Sequences of ThreeMicrobiology resource announcements · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe carboxylate platform is a promising technology for substituting petrochemicals in the provision of specific platform chemicals and liquid fuels. It includes the chain elongation process that exploits reverse β-oxidation to elongate short-chain fatty acids and forms the more valuable medium-chain variants. The pH value influences this process through multiple mechanisms and is central to effective product formation. Its influence on the microbiome dynamics was investigated during anaerobic fermentation of maize silage by combining flow cytometric short interval monitoring, cell sorting and 16S rRNA gene amplicon sequencing.
resultsCaproate and caprylate titres of up to 6.12 g L
conclusionsHigh-titre medium-chain fatty acid production in a well-established reactor design is possible using complex substrate without the addition of external electron donors. This will greatly ease scaling and profitable implementation of the process. The pH value influenced the substrate utilisation and product spectrum by shaping the microbial community. Flow cytometric single cell analysis enabled fast, short interval analysis of this community and was coupled with 16S rRNA gene amplicon sequencing to reveal the major role of lactate-producing bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.