Evidence map›Paper›PMID 31138190›Full record

SynthesisBMC surgery2019

Management of duodenal stump fistula after gastrectomy for malignant disease: a systematic review of the literature.

Maurizio Zizzo, Lara Ugoletti, Lorenzo Manzini, Carolina Castro Ruiz, Gabriela Elisa Nita, Magda Zanelli, Loredana De Marco, Giulia Besutti, Rocco Scalzone, Romano Sassatelli and 3 more

Erratum issuedOpen access · goldAbstract readSystematic Review
In one paragraph

Synthesis in BMC surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  5. Article
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  9. Review
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  12. Article
  13. Importance of duodenal stump reinforcement to prevent stump leakage after gastrectomy: a large-scale multicenter retrospective study (KSCC DELICATE study).Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Article
  14. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Maurizio ZizzoDepartment of Oncology and Advanced Technologies, Surgical Oncology Unit, Arcispedale Santa Maria Nuova di Reggio Emilia, AUSL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy. zizzomaurizio@gmail.com.ORCID http://orcid.org/0000-0001-9841-7856
Lara UgolettiGeneral and Emergency Surgery Unit, Ospedale Civile di Guastalla, AUSL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Lorenzo ManziniDepartment of Oncology and Advanced Technologies, Surgical Oncology Unit, Arcispedale Santa Maria Nuova di Reggio Emilia, AUSL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Carolina Castro RuizGeneral and Emergency Surgery Unit, Ospedale Civile di Guastalla, AUSL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Gabriela Elisa NitaDepartment of Oncology and Advanced Technologies, Surgical Oncology Unit, Arcispedale Santa Maria Nuova di Reggio Emilia, AUSL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Magda ZanelliDepartment of Oncology and Advanced Technologies, Pathology Unit, Arcispedale Santa Maria Nuova di Reggio Emilia, AUSL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Loredana De MarcoDepartment of Oncology and Advanced Technologies, Pathology Unit, Arcispedale Santa Maria Nuova di Reggio Emilia, AUSL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Giulia BesuttiDepartment of Imaging and Laboratory Medicine, Radiology Unit, Arcispedale Santa Maria Nuova di Reggio Emilia, AUSL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Rocco ScalzoneDepartment of Oncology and Advanced Technologies, Surgical Oncology Unit, Arcispedale Santa Maria Nuova di Reggio Emilia, AUSL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Romano SassatelliDepartment of Oncology and Advanced Technologies, Gastrointestinal Endoscopy Unit, Arcispedale Santa Maria Nuova di Reggio Emilia, AUSL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Valerio AnnessiGeneral and Emergency Surgery Unit, Ospedale Civile di Guastalla, AUSL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Antonio ManentiDepartment of General Surgery, Azienda Ospedaliero-Universitaria Policlinico, Del Pozzo Street 71, 41124, Modena, Italy.
Claudio PedrazzoliDepartment of Oncology and Advanced Technologies, Surgical Oncology Unit, Arcispedale Santa Maria Nuova di Reggio Emilia, AUSL-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.
Santa Maria Nuova Hospital · ITAzienda Sanitaria Unità Locale di Reggio Emilia · ITAzienda Ospedaliero-Universitaria di Modena · ITUniversity of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDuodenal stump fistula (DSF) remains one of the most serious complications following subtotal or total gastrectomy, as it endangers patient's life. DSF is related to high mortality (16-20%) and morbidity (75%) rates. DSF-related morbidity always leads to longer hospitalization times due to medical and surgical complications such as wound infections, intra-abdominal abscesses, intra-abdominal bleeding, acute pancreatitis, acute cholecystitis, severe malnutrition, fluids and electrolytes disorders, diffuse peritonitis, and pneumonia. Our systematic review aimed at improving our understanding of such surgical complication, focusing on nonsurgical and surgical DSF management in patients undergoing gastric resection for gastric cancer.

methodsWe performed a systematic literature review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guidelines. PubMed/MEDLINE, EMBASE, Scopus, Cochrane Library and Web of Science databases were used to search all related literature.

resultsThe 20 included articles covered an approximately 40 years-study period (1979-2017), with a total 294 patient population. DSF diagnosis occurred between the fifth and tenth postoperative day. Main DSF-related complications were sepsis, abdominal abscess, wound infection, pneumonia, and intra-abdominal bleeding. DSF treatment was divided into four categories: conservative (101 cases), endoscopic (4 cases), percutaneous (82 cases), and surgical (157 cases). Length of hospitalization was 21-39 days, ranging from 1 to 1035 days. Healing time was 19-63 days, ranging from 1 to 1035 days. DSF-related mortality rate recorded 18.7%.

conclusionsDSF is a rare but potentially lethal complication after gastrectomy for gastric cancer. Early DSF diagnosis is crucial in reducing DSF-related morbidity and mortality. Conservative and/or endoscopic/percutaneous treatments is/are the first choice. However, if the patient clinical condition worsens, surgery becomes mandatory and duodenostomy appears to be the most effective surgical procedure.

Indexed as

Abdominal AbscessDuodenal DiseasesGastrectomyHumansIntestinal FistulaPeritonitisPostoperative ComplicationsStomach NeoplasmsWound HealingDuodenal stumpFistulaGastrectomyGastric cancerManagementTreatment

Identifiers

PMID31138190
PMCPMC6540539
OpenAlexW2947318488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.