Evidence map›Paper›PMID 31138152›Full record

SynthesisBMC pregnancy and childbirth2019

Pregnancy-associated stroke -a systematic review of subsequent pregnancies and maternal health.

Liisa Karjalainen, Minna Tikkanen, Kirsi Rantanen, Hannele Laivuori, Mika Gissler, Petra Ijäs

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Stroke in Pregnancy: A Multidisciplinary Approach.Obstetrics and gynecology clinics of North America · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liisa KarjalainenDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. Box 700, FI-00029 HUS, Helsinki, Finland. liisa.karjalainen@helsinki.fi.ORCID http://orcid.org/0000-0002-5261-3971
Minna TikkanenDepartment of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Kirsi RantanenDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. Box 700, FI-00029 HUS, Helsinki, Finland.
Hannele LaivuoriMedical and Clinical Genetics, University of Helsinki and Helsinki University Hospital and Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Mika GisslerDepartment of Information Services, National Institute of Health and Welfare, Helsinki, Finland.
Petra IjäsDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. Box 700, FI-00029 HUS, Helsinki, Finland.

Funding

Helsingin ja Uudenmaan Sairaanhoitopiiri TYH2017106
6 · The paper itself

Abstract

backgroundPregnancy-associated stroke is a rare but life-threatening event, with an estimated incidence of 30/100000 deliveries. Data on the risk of stroke recurrence and the risk of other adverse pregnancy outcomes are essential for adequate counselling and surveillance in subsequent pregnancies. The aim of this systematic review is to describe the implications of a pregnancy-associated stroke for the future health of these women.

methodsWe searched Ovid Medline, PubMed, Cochrane Library and CINAHL for articles published in 1980-2018. Articles including women with pregnancy-associated stroke and information on at least one of the following outcomes were included: 1) recurrence of stroke during subsequent pregnancy, 2) number and course of subsequent pregnancies and their outcomes and 3) subsequent cardiovascular health.

resultsTwelve articles were included in the review, with six providing information on subsequent pregnancies, four on subsequent maternal health and two on both. The included articles varied greatly in terms of study design, length of follow up and reported outcomes. We found 252 women with pregnancy-associated stroke for whom the outcomes of interest were reported: 135 women with information on subsequent pregnancies and 123 women with information on future health. In total, 55 pregnancies after stroke were found. In the majority of studies, the incidence of pregnancy complications was comparable to that of the general population. The risk of stroke recurrence during pregnancy was 2%. Data on subsequent health of these women were limited, and the quality of the data varied between the studies.

conclusionsData on subsequent pregnancies and health of women with a history of pregnancy-associated stroke are limited. Further research on this topic is essential for adequate counselling and secondary prevention.

Indexed as

Maternal HealthFemaleGravidityHumansPregnancyPregnancy ComplicationsPregnancy OutcomeRecurrenceSecondary PreventionStrokeCardiovascular diseaseFollow-upFuture healthPostpartum periodPregnancyPregnancy-associated strokePregnancy outcomePuerperiumRecurrenceStrokeSubsequent pregnancies

Identifiers

PMID31138152
PMCPMC6540366

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.