Evidence map›Paper›PMID 31138020›Full record

Trial reportCirculation research2019

G-CSF for Extensive STEMI.

Felice Achilli, Gianluca Pontone, Beatrice Bassetti, Lidia Squadroni, Jeness Campodonico, Elena Corrada, Camilla Facchini, Luca Mircoli, Giovanni Esposito, Daniele Scarpa and 16 more

Registry-linked trialOpen access · bronzeAbstract readClinical Trial, Phase IIIComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Trial report in Circulation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969890 (Phase III Study on STem cElls Mobilization in Acute Myocardial Infarction), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01969890 phase3terminatednot on this map

Phase III Study on STem cElls Mobilization in Acute Myocardial Infarction

TypeinterventionalSponsorHeart Care FoundationRan2013 to 2018Enrolled532ConditionsAnterior Acute Myocardial Infarction, Left Ventricular Systolic DysfunctionArmsG-CSF administration
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 13 institutions in 1 country.

Felice AchilliFrom the Departments of Cardiology (F.A., S.R., C.M., F.S.), ASST-Monza, San Gerardo Hospital, Monza, Italy.
Gianluca PontoneCardiovascular Imaging (G. Pontone, M.G., G.M., A.B.), Centro Cardiologico Monzino IRCCS, Milano, Italy.
Beatrice BassettiVascular Biology and Regenerative Medicine Unit (B.B., G. Pompilio), Centro Cardiologico Monzino IRCCS, Milano, Italy.
Lidia SquadroniDepartment of Cardiology, San Carlo Borromeo Hospital, Milano, Italy (L.S.).
Jeness CampodonicoIntensive Cardiac Care Unit (J.C.), Centro Cardiologico Monzino IRCCS, Milano, Italy.
Elena CorradaCardiovascular Department, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy (E.C.).
Camilla FacchiniCardiology, Bassini Hospital, Cinisello Balsamo, Italy (C.F.).
Luca MircoliCardiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy (L.M.).
Giovanni EspositoDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, Napoli, Italy (G.E.).
Daniele ScarpaCardiology, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (D.S.).
Stefano PidelloCardiology, Città della Salute e della Scienza University Hospital of Torino, Italy (S.P.).
Stefano RighettiFrom the Departments of Cardiology (F.A., S.R., C.M., F.S.), ASST-Monza, San Gerardo Hospital, Monza, Italy.
Filiberto Di GennaroRadiology (F.D.G.), ASST-Monza, San Gerardo Hospital, Monza, Italy.
Marco GuglielmoCardiovascular Imaging (G. Pontone, M.G., G.M., A.B.), Centro Cardiologico Monzino IRCCS, Milano, Italy.
Giuseppe MuscogiuriCardiovascular Imaging (G. Pontone, M.G., G.M., A.B.), Centro Cardiologico Monzino IRCCS, Milano, Italy.
Andrea BaggianoCardiovascular Imaging (G. Pontone, M.G., G.M., A.B.), Centro Cardiologico Monzino IRCCS, Milano, Italy.
Alberto LimidoCoronary Intensive Care Unit, ASST-Settelaghi, Ospedale di Circolo-Fondazione Macchi, Varese, Italy (A.L.).
Laura LenattiCardiology, Alessandro Manzoni Hospital, Lecco, Italy (L.L.).
Giuseppe Di TanoCardiology, ASST of Cremona, Italy (G.D.T.).
Cristina MalafronteFrom the Departments of Cardiology (F.A., S.R., C.M., F.S.), ASST-Monza, San Gerardo Hospital, Monza, Italy.
Federica SofficiFrom the Departments of Cardiology (F.A., S.R., C.M., F.S.), ASST-Monza, San Gerardo Hospital, Monza, Italy.
Martina CeseriANMCO Research Center, Heart Care Foundation, Firenze, Italy (M.C.).
Stefano MaggioliniCardiology, San Leopoldo Mandic Hospital, Merate, Italy (S.M.).
Gualtiero I ColomboImmunology and Functional Genomics Unit (G.I.C.), Centro Cardiologico Monzino IRCCS, Milano, Italy.
Giulio PompilioVascular Biology and Regenerative Medicine Unit (B.B., G. Pompilio), Centro Cardiologico Monzino IRCCS, Milano, Italy.
STEM-AMI OUTCOME CMR Sub-Study Investigators
Centro Cardiologico Monzino · ITAzienda Ospedaliera San Gerardo · ITAlessandro Manzoni Hospital · ITAssociazione Nazionale Medici Cardiologi Ospedalieri · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHumanitas University · ITIstituti Ospitalieri di Cremona · ITOspedale Bassini · ITOspedale di Circolo e Fondazione Macchi · ITOspedale San Carlo · ITUniversity of Naples Federico II · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleIn the exploratory Phase II STEM-AMI (Stem Cells Mobilization in Acute Myocardial Infarction) trial, we reported that early administration of G-CSF (granulocyte colony-stimulating factor), in patients with anterior ST-segment-elevation myocardial infarction and left ventricular (LV) dysfunction after successful percutaneous coronary intervention, had the potential to significantly attenuate LV adverse remodeling in the long-term.

objectiveThe STEM-AMI OUTCOME CMR (Stem Cells Mobilization in Acute Myocardial Infarction Outcome Cardiac Magnetic Resonance) Substudy was adequately powered to evaluate, in a population showing LV ejection fraction ≤45% after percutaneous coronary intervention for extensive ST-segment-elevation myocardial infarction, the effects of early administration of G-CSF in terms of LV remodeling and function, infarct size assessed by late gadolinium enhancement, and myocardial strain. METHODS AND

resultsWithin the Italian, multicenter, prospective, randomized, Phase III STEM-AMI OUTCOME trial, 161 ST-segment-elevation myocardial infarction patients were enrolled in the CMR Substudy and assigned to standard of care (SOC) plus G-CSF or SOC alone. In 119 patients (61 G-CSF and 58 SOC, respectively), CMR was available at baseline and 6-month follow-up. Paired imaging data were independently analyzed by 2 blinded experts in a core CMR lab. The 2 groups were similar for clinical characteristics, cardiovascular risk factors, and pharmacological treatment, except for a trend towards a larger infarct size and longer symptom-to-balloon time in G-CSF patients. ANCOVA showed that the improvement of LV ejection fraction from baseline to 6 months was 5.1% higher in G-CSF patients versus SOC (P=0.01); concurrently, there was a significant between-group difference of 6.7 mL/m

conclusionsEarly administration of G-CSF exerted a beneficial effect on top of SOC in patients with LV dysfunction after extensive ST-segment-elevation myocardial infarction in terms of global systolic function, adverse remodeling, scar size, and myocardial strain. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT01969890.

Indexed as

AgedFemaleGranulocyte Colony-Stimulating FactorHeart VentriclesHumansMaleMiddle AgedMyocardial ContractionOrgan SizeProspective StudiesSingle-Blind MethodST Elevation Myocardial InfarctionStroke VolumeVentricular RemodelingGranulocyte Colony-Stimulating Factorgranulocyte colony-stimulating factorleft ventricular remodelingmyocardial infarctionpercutaneous coronary interventionstandard of care

Identifiers

PMID31138020
OpenAlexW2947576810

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.