ArticleJournal of clinical medicine2019
Impact of Lymphocyte and Neutrophil Counts on Mortality Risk in Severe Community-Acquired Pneumonia with or without Septic Shock.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictors of mortality in severe pneumonia patients: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- An immune-inflammatory dysregulation score for risk stratification of 28-day all-cause mortality in critically ill patients with severe community-acquired pneumonia.Frontiers in medicine · 2026Article
- Clinical decision-making in pediatric pneumonia: when to consider interventional: procedures? A retrospective cross-sectional study.Annals of medicine and surgery (2012) · 2025Article
- Antibiotics for Paediatric Community-Acquired Pneumonia: What is the Optimal Course Duration?Paediatric drugs · 2025Review
- Development and validation of a clinical prediction model for in-hospital mortality of severe pneumonia based on machine learning.Frontiers in pharmacology · 2025Article
- Identifying severe community-acquired pneumonia using radiomics and clinical data: a machine learning approach.Scientific reports · 2024Article
- Endotypes of Paediatric Cough-Do They Exist and Finding New Techniques to Improve Clinical Outcomes.Journal of clinical medicine · 2024Review
- Hyaluronic Acid is Associated with Severity and Prognosis in Patients with Community-Acquired Pneumonia.Journal of inflammation research · 2024Article
- Host Response in Critically Ill Patients Aged 65 Years or Older: A Prospective Study.Clinical interventions in aging · 2024Article
- Clinical relevance of neutrophil/lymphocyte ratio combined with APACHEII for prognosis of severe heatstroke.Heliyon · 2023Article
- Observational
- Physiological stress level and screening for malnutrition as preoperative predictors of postoperative complications in pancreatic surgery: a retrospective study.BMC surgery · 2023Article
- Effects of lymphocyte and neutrophil counts and their time courses on mortality in patients with postoperative pneumonia.Scientific reports · 2022Observational
- Why the application of IVIG might be beneficial in patients with COVID-19.The Lancet. Respiratory medicine · 2022Article
- Effect Observation of Optimized Individualized Nursing Care Applied to ICU Patients with Severe Pneumonia.Emergency medicine international · 2022Article
- Mechanistic insights into cell-free hemoglobin-induced injury during septic shock.American journal of physiology. Heart and circulatory physiology · 2021Article
- Thymosin α1 therapy in critically ill patients with COVID-19: A multicenter retrospective cohort study.International immunopharmacology · 2020Article
- Prognostic factors for ARDS: clinical, physiological and atypical immunodeficiency.BMC pulmonary medicine · 2020Observational
- In canine bacterial pneumonia circulating granulocyte counts determine outcome from donor cells.Transfusion · 2020Article
- Biomarkers in Community-Acquired Pneumonia (Cardiac and Non-Cardiac).Journal of clinical medicine · 2020Review
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCommunity-acquired pneumonia (CAP) is a frequent cause of death worldwide. As recently described, CAP shows different biological endotypes. Improving characterization of these endotypes is needed to optimize individualized treatment of this disease. The potential value of the leukogram to assist prognosis in severe CAP has not been previously addressed.
methodsA cohort of 710 patients with CAP admitted to the intensive care units (ICUs) at Hospital of Mataró and Parc Taulí Hospital of Sabadell was retrospectively analyzed. Patients were split in those with septic shock (
resultsMultivariate analysis demonstrated that lymphopenia <675 cells/mm
conclusionlymphopenia is a preserved risk factor for mortality across the different clinical presentations of severe CAP (sCAP), while failing to expand circulating neutrophils counts beyond the upper limit of normality represents an incremental immunological failure observed just in those patients with the most severe form of CAP, septic shock.
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