Evidence map›Paper›PMID 31137813›Full record

ArticleMolecules (Basel, Switzerland)2019

Picroside II Isolated from

Kiram Lee, Jin Choi, Bo Kyong Choi, Young-Mi Gu, Hyung Won Ryu, Sei-Ryang Oh, Hyun-Jun Lee

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kiram LeeNatural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju, Chungbuk 28116, Korea. krl05@kribb.re.kr.ORCID 0000-0002-1680-616X
Jin ChoiNatural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju, Chungbuk 28116, Korea. chojinsg@gail.com.
Bo Kyong ChoiNatural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju, Chungbuk 28116, Korea. bkchoi@progen.co.kr.
Young-Mi GuNatural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju, Chungbuk 28116, Korea. kuy823@kribb.re.kr.
Hyung Won RyuNatural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju, Chungbuk 28116, Korea. ryuhw@kribb.re.kr.
Sei-Ryang OhNatural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju, Chungbuk 28116, Korea. seiryang@kribb.re.kr.
Hyun-Jun LeeNatural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju, Chungbuk 28116, Korea. hjlee7@kribb.re.kr.ORCID 0000-0003-1293-6159
Korea Research Institute of Bioscience and Biotechnology · KR

Funding

National Research Foundation of Korea 2017R1A2B4008163
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is a major inflammatory lung disease characterized by irreversible and progressive airflow obstruction. Although corticosteroids are often used to reduce inflammation, steroid therapies are insufficient in patients with refractory COPD. Both serum amyloid A (SAA) and IL-33 have been implicated in the pathology of steroid-resistant lung inflammation. Picroside II isolated from

Indexed as

CinnamatesEpithelial CellsGlucocorticoidsHumansInterleukin-33Iridoid GlucosidesLipopolysaccharidesLungMAP Kinase Signaling SystemMonocytesNF-kappa BPlantaginaceaeSerum Amyloid A ProteinTHP-1 CellsToll-Like Receptor 2Toll-Like Receptor 4CinnamatesGlucocorticoidsInterleukin-33Iridoid GlucosidesLipopolysaccharidesNF-kappa Bpicroside IISerum Amyloid A ProteinToll-Like Receptor 2Toll-Like Receptor 4airway epithelial cellsIL-33Picroside IIPseudolysimachion rotundum var. subintegrumserum amyloid Asteroid-resistance

Identifiers

PMID31137813
PMCPMC6572537
OpenAlexW2947131946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.