Evidence map›Paper›PMID 31137777›Full record

ReviewInternational journal of molecular sciences2019

The Anti-inflammatory Effects of Dietary Anthocyanins against Ulcerative Colitis.

Shiyu Li, Binning Wu, Wenyi Fu, Lavanya Reddivari

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05774613 (Bioavailability of Antioxidant Compounds and Effect on Markers of Inflammation by Ingestion of a Hibiscus Sabdariffa Beverage With Glicemic and Insulinemic Response), which is not on this map. Cited by 68 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 3 pooled it
5.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05774613 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Bioavailability of Antioxidant Compounds and Effect on Markers of Inflammation by Ingestion of a Hibiscus Sabdariffa Beverage With Glicemic and Insulinemic Response

TypeinterventionalSponsorInstituto Tecnológico y de Estudios Superiores de OccidenteRan2021 to 2023Enrolled12ConditionsMarkers of Inflammation, Hyperglycemia, Postprandial, HyperinsulinismArmsEffect of a Hibiscus sabdariffa beverage
3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 3 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Pooled it
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  18. Phytochemical Analysis, Computational Study, and in vitro Assay ofJournal of experimental pharmacology · 2025
    Article
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  20. Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Shiyu LiDepartment of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907, USA. li3291@purdue.edu.
Binning WuDepartment of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907, USA. wu1515@purdue.edu.
Wenyi FuDepartment of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907, USA. fu205@purdue.edu.
Lavanya ReddivariDepartment of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907, USA. lreddiva@purdue.edu.
Purdue University West Lafayette · USPennsylvania State University · US

Funding

National Institute of Food and Agriculture 2016-67017-24512
6 · The paper itself

Abstract

Ulcerative colitis (UC), which is a major form of inflammatory bowel disease (IBD), is a chronic relapsing disorder of the gastrointestinal tract affecting millions of people worldwide. Alternative natural therapies, including dietary changes, are being investigated to manage or treat UC since current treatment options have serious negative side effects. There is growing evidence from animal studies and human clinical trials that diets rich in anthocyanins, which are pigments in fruits and vegetables, protect against inflammation and increased gut permeability as well as improve colon health through their ability to alter bacterial metabolism and the microbial milieu within the intestines. In this review, the structure and bioactivity of anthocyanins, the role of inflammation and gut bacterial dysbiosis in UC pathogenesis, and their regulation by the dietary anthocyanins are discussed, which suggests the feasibility of dietary strategies for UC mitigation.

Indexed as

AnimalsAnthocyaninsAnti-Inflammatory AgentsColitis, UlcerativeDietary SupplementsHumansAnthocyaninsAnti-Inflammatory Agentsanthocyaninsanti-inflammatorycolitiscolonic inflammation

Identifiers

PMID31137777
PMCPMC6567294
OpenAlexW2947971523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.