Evidence map›Paper›PMID 31137744›Full record

ReviewBiomolecules2019

Nanoparticle Activation Methods in Cancer Treatment.

Benjamin D White, Chengchen Duan, Helen E Townley

Abstract readReview
In one paragraph

Review in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Benjamin D WhiteDepartment of Engineering Science, Oxford University, Parks Road, OX1 3PJ, Oxford, UK. Benjamin.White@seh.ox.ac.uk.
Chengchen DuanNuffield department of Women's and Reproductive Health, Oxford University John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK. Chengchen.Duan@wolfson.ox.ac.uk.
Helen E TownleyDepartment of Engineering Science, Oxford University, Parks Road, OX1 3PJ, Oxford, UK. helen.townley@wrh.ox.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this review, we intend to highlight the progress which has been made in recent years around different types of smart activation nanosystems for cancer treatment. Conventional treatment methods, such as chemotherapy or radiotherapy, suffer from a lack of specific targeting and consequent off-target effects. This has led to the development of smart nanosystems which can effect specific regional and temporal activation. In this review, we will discuss the different methodologies which have been designed to permit activation at the tumour site. These can be divided into mechanisms which take advantage of the differences between healthy cells and cancer cells to trigger activation, and those which activate by a mechanism extrinsic to the cell or tumour environment.

Indexed as

AnimalsAntineoplastic AgentsDrug CarriersDrug LiberationHumansNanoparticlesNeoplasmsProdrugsStimuli Responsive PolymersAntineoplastic AgentsDrug CarriersProdrugsStimuli Responsive Polymerscancer, tumour, activation, nanosystems, temporal, spatial, extrinsic, intrinsic

Identifiers

PMID31137744
PMCPMC6572460

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.